methyl (2S)-3-methyl-2-{N-[3-(2-{3-[(4-methylphenyl)sulfanyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}butanoate

Base Information

Chemical Name:methyl (2S)-3-methyl-2-{N-[3-(2-{3-[(4-methylphenyl)sulfanyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}butanoate
CAS No.:1362825-47-5
Molecular Formula:C₃₂H₃₃NO₄S₂
Molecular Weight:559.75
Hs Code.:

Synonyms:methyl (2S)-3-methyl-2-{N-[3-(2-{3-[(4-methylphenyl)sulfanyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}butanoate

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Chemical Property of methyl (2S)-3-methyl-2-{N-[3-(2-{3-[(4-methylphenyl)sulfanyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}butanoate

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Technology Process of methyl (2S)-3-methyl-2-{N-[3-(2-{3-[(4-methylphenyl)sulfanyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}butanoate

There total 4 articles about methyl (2S)-3-methyl-2-{N-[3-(2-{3-[(4-methylphenyl)sulfanyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₉NO₇S₂

: 106-45-6
para-thiocresol

: 1362825-47-5
methyl (2S)-3-methyl-2-{N-[3-(2-{3-[(4-methylphenyl)sulfanyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}butanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jo202580y

Reference yield:

: 1253043-95-6
1-iodo-2-(3-iodoprop-1-ynyl)benzene

: 1362825-47-5
methyl (2S)-3-methyl-2-{N-[3-(2-{3-[(4-methylphenyl)sulfanyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine / tetrahydrofuran / 4.75 h / 40 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo202580y

Reference yield:

: 1362825-41-9
methyl (2S)-2-{N-[3-(2-iodophenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}-3-methylbutanoate

: 1362825-47-5
methyl (2S)-3-methyl-2-{N-[3-(2-{3-[(4-methylphenyl)sulfanyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine / tetrahydrofuran / 4.75 h / 40 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo202580y