methyl 3-methyl-2-{N-[(3-{[(4-methylbenzene)sulfonyl]methyl}naphthalen-2-yl)methyl](4-methylbenzene)sulfonamido}but-2-enoate

Base Information

Chemical Name:methyl 3-methyl-2-{N-[(3-{[(4-methylbenzene)sulfonyl]methyl}naphthalen-2-yl)methyl](4-methylbenzene)sulfonamido}but-2-enoate
CAS No.:1362826-25-2
Molecular Formula:C₃₂H₃₃NO₆S₂
Molecular Weight:591.749
Hs Code.:

Synonyms:methyl 3-methyl-2-{N-[(3-{[(4-methylbenzene)sulfonyl]methyl}naphthalen-2-yl)methyl](4-methylbenzene)sulfonamido}but-2-enoate

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Chemical Property of methyl 3-methyl-2-{N-[(3-{[(4-methylbenzene)sulfonyl]methyl}naphthalen-2-yl)methyl](4-methylbenzene)sulfonamido}but-2-enoate

Chemical Property:

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Technology Process of methyl 3-methyl-2-{N-[(3-{[(4-methylbenzene)sulfonyl]methyl}naphthalen-2-yl)methyl](4-methylbenzene)sulfonamido}but-2-enoate

There total 7 articles about methyl 3-methyl-2-{N-[(3-{[(4-methylbenzene)sulfonyl]methyl}naphthalen-2-yl)methyl](4-methylbenzene)sulfonamido}but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1362826-23-0
methyl (2S)-3-methyl-2-{N-[(3-{[(4-methylbenzene)sulfonyl]-methyl}naphthalen-2-yl)methyl](4-methylbenzene)-sulfonamido}but-3-enoate

: 1362826-25-2
methyl 3-methyl-2-{N-[(3-{[(4-methylbenzene)sulfonyl]methyl}naphthalen-2-yl)methyl](4-methylbenzene)sulfonamido}but-2-enoate

Guidance literature:: With mesoporous silica grafted with a tertiary amino group (GA-SBA-15); In acetonitrile; at 80 ℃; for 168h; Inert atmosphere;
DOI:10.1021/jo202580y

Reference yield:

: methyl 3-methyl-2-{N-[3-(2-{3-[(4-methylbenzene)sulfonyl]prop-1-yn-1-yl}phenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}butanoate

: C₃₂H₃₃NO₆S₂

: 1362826-25-2
methyl 3-methyl-2-{N-[(3-{[(4-methylbenzene)sulfonyl]methyl}naphthalen-2-yl)methyl](4-methylbenzene)sulfonamido}but-2-enoate

Guidance literature:: With mesoporous silica grafted with a tertiary amino group (2 equiv); In acetonitrile; at 80 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jo202580y

Reference yield:

: C₂₆H₂₉NO₇S₂

: 1362826-25-2
methyl 3-methyl-2-{N-[(3-{[(4-methylbenzene)sulfonyl]methyl}naphthalen-2-yl)methyl](4-methylbenzene)sulfonamido}but-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.67 h / 0 °C / Inert atmosphere

3: mesoporous silica grafted with a tertiary amino group (GA-SBA-15) / acetonitrile / 18 h / 80 °C / Inert atmosphere

4: mesoporous silica grafted with a tertiary amino group (GA-SBA-15) / acetonitrile / 168 h / 80 °C / Inert atmosphere

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jo202580y