6,7-dimethoxy-3-(2-oxo-2-phenylethyl)isobenzofuran-1(3H)-one

Base Information

• Chemical Name: 6,7-dimethoxy-3-(2-oxo-2-phenylethyl)isobenzofuran-1(3H)-one
• CAS No.: 302938-38-1
• Molecular Formula: C₁₈H₁₆O₅
• Molecular Weight: 312.322
• Mol file: 302938-38-1.mol

Synonyms:6,7-dimethoxy-3-(2-oxo-2-phenylethyl)isobenzofuran-1(3H)-one

Chemical Property of 6,7-dimethoxy-3-(2-oxo-2-phenylethyl)isobenzofuran-1(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7-dimethoxy-3-(2-oxo-2-phenylethyl)isobenzofuran-1(3H)-one

There total 5 articles about 6,7-dimethoxy-3-(2-oxo-2-phenylethyl)isobenzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-oxo-3-phenylpropionic acid (614-20-0) + 2-formyl-3,4-dimethoxy-benzoic acid (483-85-2) → 6,7-dimethoxy-3-(2-oxo-2-phenylethyl)isobenzofuran-1(3H)-one (302938-38-1)

Guidance literature:

With 4-methoxy-aniline; In glycerol; at 65 ℃; for 0.5h; Cooling; Green chemistry;

DOI:10.3762/bjoc.13.139

Reference yield: 55.0%

1-phenylcyclopropan-1-ol (29526-96-3) + 2,3-dimethoxybenzoic acid (1521-38-6) → 6,7-dimethoxy-3-(2-oxo-2-phenylethyl)isobenzofuran-1(3H)-one (302938-38-1)

Guidance literature:

With potassium phosphate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; In acetonitrile; at 80 ℃; for 24h; Sealed tube; Molecular sieve;

DOI:10.1039/d1cc01778k

Reference yield:

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) → 6,7-dimethoxy-3-(2-oxo-2-phenylethyl)isobenzofuran-1(3H)-one (302938-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: titanium(IV) isopropylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; potassium phosphate / acetonitrile / 24 h / 80 °C / Sealed tube; Molecular sieve

With titanium(IV) isopropylate; potassium phosphate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; In tetrahydrofuran; acetonitrile;

DOI:10.1039/d1cc01778k

upstream raw materials:

opianic acid

acetophenone

3-oxo-3-phenylpropionic acid

2-formyl-3,4-dimethoxy-benzoic acid

Downstream raw materials:

opianic acid

acetophenone

6,7-dimethoxy-2-phenyl-3H-isochromeno[3,4-b]pyrrol-5-one