(5-(bis(2-bromoethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazine-1-yl)methanone

Base Information

Chemical Name:(5-(bis(2-bromoethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazine-1-yl)methanone
CAS No.:1563184-80-4
Molecular Formula:C₁₈H₂₆Br₂N₄O₅S
Molecular Weight:570.302
Hs Code.:

Synonyms:(5-(bis(2-bromoethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazine-1-yl)methanone

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Chemical Property of (5-(bis(2-bromoethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazine-1-yl)methanone

Chemical Property:

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Technology Process of (5-(bis(2-bromoethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazine-1-yl)methanone

There total 6 articles about (5-(bis(2-bromoethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazine-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1563184-81-5
(5-(bis(2-chloroethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazine-1-yl)methanone

: 1563184-80-4
(5-(bis(2-bromoethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazine-1-yl)methanone

Guidance literature:: With lithium bromide; Reflux;

Reference yield:

: 34036-07-2
3,4 difluorobenzaldehyde

: 1563184-80-4
(5-(bis(2-bromoethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazine-1-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1: dimethyl sulfoxide / 3 h / 75 °C / Inert atmosphere

2: sodium dihydrogen phosphate monohydrate; dihydrogen peroxide; sodium chlorite; hydrogenchloride / acetonitrile; water / 0 - 20 °C

3: sulfuric acid; nitric acid / 4 h / 45 °C

4: dimethyl sulfoxide / 2 h / 45 °C

5: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

6: dichloromethane; tetrahydrofuran / 0.5 h / 0 - 20 °C

7: lithium bromide / Reflux

With hydrogenchloride; sodium chlorite; thionyl chloride; sodium dihydrogen phosphate monohydrate; sulfuric acid; dihydrogen peroxide; nitric acid; N,N-dimethyl-formamide; lithium bromide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 185945-88-4
3-fluoro-4-(methylsulfonyl)benzoic acid

: 1563184-80-4
(5-(bis(2-bromoethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazine-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / 4 h / 45 °C

2: dimethyl sulfoxide / 2 h / 45 °C

3: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

4: dichloromethane; tetrahydrofuran / 0.5 h / 0 - 20 °C

5: lithium bromide / Reflux

With thionyl chloride; sulfuric acid; nitric acid; N,N-dimethyl-formamide; lithium bromide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;