(+/-)-(3-chlorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

Base Information

Chemical Name:(+/-)-(3-chlorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride
CAS No.:1092477-67-2
Molecular Formula:C₁₃H₁₇ClN₂O₂*ClH
Molecular Weight:305.204
Hs Code.:

Synonyms:(+/-)-(3-chlorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

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Chemical Property of (+/-)-(3-chlorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

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Technology Process of (+/-)-(3-chlorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

There total 2 articles about (+/-)-(3-chlorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 109-01-3
1-methyl-piperazine

: 3381-74-6
α-Bromo-(3-chlorophenyl)acetic acid

: 1092477-67-2
(+/-)-(3-chlorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

Guidance literature:: α-Bromo-(3-chlorophenyl)acetic acid; With potassium carbonate; In tetrahydrofuran; for 0.0833333h;

1-methyl-piperazine; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

: 1878-65-5
3-chlorophenylacetic acid

: 1092477-67-2
(+/-)-(3-chlorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Heating / reflux

2.1: potassium carbonate / tetrahydrofuran / 0.08 h

2.2: 5 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane;

Reference yield: 91.0%

: 1092477-67-2
(+/-)-(3-chlorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

: 39943-56-1
3,5-dichlorophenylhydrazine

: 1092477-68-3
(+/-)-2-(3-chlorophenyl)-N'-(3,5-dichlorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Guidance literature:: (+/-)-(3-chlorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 0.166667h;

3,5-dichlorophenylhydrazine; In dichloromethane; at 20 ℃;