3-(4-methoxybenzyl)indoline

Base Information

• Chemical Name: 3-(4-methoxybenzyl)indoline
• CAS No.: 214615-05-1
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.317
• Mol file: 214615-05-1.mol

Synonyms:3-(4-methoxybenzyl)indoline

Chemical Property of 3-(4-methoxybenzyl)indoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(4-methoxybenzyl)indoline

There total 3 articles about 3-(4-methoxybenzyl)indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-[(4-methoxyphenyl)methyl]-1H-indole (22044-95-7) → 3-(4-methoxybenzyl)indoline (214615-05-1)

Guidance literature:

With potassium tert-butylate; hydrogen; C₃₁H₃₁BrMnNO₂P₂; In toluene; at 130 ℃; for 36h; under 37503.8 Torr; chemoselective reaction; Autoclave;

DOI:10.1021/acs.orglett.0c01273

Reference yield:

indole (120-72-9) → 3-(4-methoxybenzyl)indoline (214615-05-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate; hydrogen; C₃₁H₃₁BrMnNO₂P₂ / toluene / 36 h / 100 °C / 37503.8 Torr / Autoclave

2: cesiumhydroxide monohydrate / toluene / 20 h / 135 °C / Sealed tube; Inert atmosphere

3: potassium tert-butylate; hydrogen; C₃₁H₃₁BrMnNO₂P₂ / toluene / 36 h / 130 °C / 37503.8 Torr / Autoclave

With cesiumhydroxide monohydrate; potassium tert-butylate; hydrogen; C₃₁H₃₁BrMnNO₂P₂; In toluene;

DOI:10.1021/acs.orglett.0c01273

Reference yield:

1-indoline (496-15-1) + 4-Methoxybenzyl alcohol (105-13-5) → 3-(4-methoxybenzyl)indoline (214615-05-1)

Guidance literature:

Multi-step reaction with 2 steps

1: cesiumhydroxide monohydrate / toluene / 20 h / 135 °C / Sealed tube; Inert atmosphere

2: potassium tert-butylate; hydrogen; C₃₁H₃₁BrMnNO₂P₂ / toluene / 36 h / 130 °C / 37503.8 Torr / Autoclave

With cesiumhydroxide monohydrate; potassium tert-butylate; hydrogen; C₃₁H₃₁BrMnNO₂P₂; In toluene;

DOI:10.1021/acs.orglett.0c01273

upstream raw materials:

3-[(4-methoxyphenyl)methyl]-1H-indole

indole

1-indoline

4-Methoxybenzyl alcohol