C₃₂H₃₀N₃O₁₀P

Base Information

Chemical Name:C₃₂H₃₀N₃O₁₀P
CAS No.:1608113-63-8
Molecular Formula:C₃₂H₃₀N₃O₁₀P
Molecular Weight:647.578
Hs Code.:

C<sub>32</sub>H<sub>30</sub>N<sub>3</sub>O<sub>10</sub>P

Synonyms:C₃₂H₃₀N₃O₁₀P

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₃₂H₃₀N₃O₁₀P

Chemical Property:

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Technology Process of C₃₂H₃₀N₃O₁₀P

There total 4 articles about C₃₂H₃₀N₃O₁₀P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 161322-80-1
3'-O-phthalimido-2'-deoxythymidine

: 1608113-63-8
C₃₂H₃₀N₃O₁₀P

Guidance literature:: Dibenzyl N,N-diisopropylphosphoramidite; 3'-O-phthalimido-2'-deoxythymidine; With 1H-tetrazole; In dichloromethane; acetonitrile; at 0 - 20 ℃; for 12h; Inert atmosphere;

With dihydrogen peroxide; In dichloromethane; acetonitrile; at -40 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.201301781

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 1608113-63-8
C₃₂H₃₀N₃O₁₀P

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; dmap / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2.1: triethylamine; methanesulfonyl chloride / 2 h / 20 °C / Inert atmosphere

2.2: 1.5 h / Inert atmosphere; Reflux

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 2 h / 0 - 20 °C / Inert atmosphere

4.1: acetic acid / 3 h / 20 °C / Inert atmosphere

5.1: 1H-tetrazole / dichloromethane; acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

5.2: 2 h / -40 - 20 °C / Inert atmosphere

With 1H-tetrazole; dmap; di-isopropyl azodicarboxylate; acetic acid; methanesulfonyl chloride; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201301781

Reference yield:

: 42926-80-7
5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

: 1608113-63-8
C₃₂H₃₀N₃O₁₀P

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; methanesulfonyl chloride / 2 h / 20 °C / Inert atmosphere

1.2: 1.5 h / Inert atmosphere; Reflux

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 2 h / 0 - 20 °C / Inert atmosphere

3.1: acetic acid / 3 h / 20 °C / Inert atmosphere

4.1: 1H-tetrazole / dichloromethane; acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

4.2: 2 h / -40 - 20 °C / Inert atmosphere

With 1H-tetrazole; di-isopropyl azodicarboxylate; acetic acid; methanesulfonyl chloride; triethylamine; triphenylphosphine; In dichloromethane; toluene; acetonitrile; 2.1: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201301781