42926-80-7

Basic information

• Product Name: Thymidine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-
• CAS NO: 42926-80-7
• Molecular Formula: C30H30N2O6
• Molecular Weight: 514.578
• Mol File: 42926-80-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 103-105 °C
• Density: 1.274±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Thymidine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-(42926-80-7)
• EPA Substance Registry System: Thymidine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-(42926-80-7)

Safety Data

• Hazardous Substances Data: 42926-80-7(Hazardous Substances Data)

Upstream product

• 90173-59-4 4-methoxytriphenylmethyl trifluoroacetate 
• 50-89-5 thymidine 
• 847-83-6 p-methoxytrityl alcohol 
• 1333311-80-0 benzyl p-monomethoxytrityl ether 
• 923928-59-0 C₃₆H₄₂N₂O₇S₂ 
• 923928-62-5 C₄₅H₅₉N₄O₈PS₂ 
• 14470-28-1 mono-4-methoxytrityl chloride 

Downstream Products

• 72718-36-6 Phosphoric acid (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester dimethyl ester 
• 76512-81-7 Phosphoric acid (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester; compound with pyridine 
• 76512-74-8 Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester 
• 76512-80-6 Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with pyridine 
• 87507-07-1 C₄₈H₅₄N₇O₁₄P 
• 87471-40-7 C₅₀H₅₂N₅O₁₄P 
• 87491-49-4 C₅₂H₅₄N₅O₁₅P 
• 62930-00-1 O^3'-(4,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphol-2-yl)-O^5'-(4-methoxy-trityl)-thymidine 
• 139213-01-7 (S)-Methyl-phosphonic acid (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester 
• 78272-45-4 Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,O'-dimethyl ester 
• 74706-78-8 (5'-O-Monomethoxytritylthymidin-3')(2,5-dichlorphenyl)(p-nitrophenylaethyl)phosphorsaeureester 
• 57777-76-1 O^5'-(4-methoxy-trityl)-[3']thymidylic acid mono-(2-chloro-phenyl) ester 
• 74706-79-9 Phosphoric acid 2-(2-chloro-4-nitro-phenyl)-ethyl ester 2,5-dichloro-phenyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 61941-22-8 5'-O-monomethoxytritylthymidine 3'-O-(2-chlorophenyl) phosphoranilidate 

Relevant articles and documents

METHOD FOR PREPARING 3'-O-AMINO-2'-DEOXYRIBONUCLEOSIDE-5'-TRIPHOSPHATE

The invention relates to a method for preparing 3 ' -O-amino-2' -deoxyribonucleoside-5 ' - triphosphate. It also relates to a solid support functionalized with at least one N- hydroxyphthalimide moiety and uses thereof for protecting 3 '-hydroxy group of a 2'- deoxyribonucleoside during synthesis of a nucleoside or a derivative thereof.

Tailoring peptide-nucleotide conjugates (PNCs) for nucleotide delivery in bacterial cells

The design and synthesis of peptide-2′-deoxythymidine-5′-O- monophosphate conjugates as potential active delivery systems for nucleotides into auxotrophic E. coli strains is presented. A series of oligopeptides were allowed to react with 5′-O-(dibenzylphosphate)-2′-deoxythymidine or its suitably 3′-derivatized analogues to give the relevant peptide-nucleotide adducts, by the formation of a biolabile chemical connection. Using strategies based on the principles of orthogonal protection and activation, rational variations were made to the linker and the peptide moiety in order to tune the metabolic stability of the conjugates.

A solvent free and selective method for preparation of triphenylmethyl ethers of alcohols and nucleosides

A very simple and efficient method is described for protection of alcohols and nucleosides with trityl(triphenylmethyl), mono and dimethoxytrityl chlorides in the presence of triethylamine under microwave irradiation. High selectivity was observed for tritylation of 5'-OH function of nucleosides.