4-Chloro-N-(5-formyl-6,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide

Base Information

Chemical Name:4-Chloro-N-(5-formyl-6,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide
CAS No.:165538-00-1
Molecular Formula:C₁₉H₂₀ClNO₃S
Molecular Weight:377.892
Hs Code.:

Synonyms:4-Chloro-N-(5-formyl-6,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide

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Chemical Property of 4-Chloro-N-(5-formyl-6,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide

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Technology Process of 4-Chloro-N-(5-formyl-6,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide

There total 5 articles about 4-Chloro-N-(5-formyl-6,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 594-27-4
tetramethylstannane

: 210535-29-8
N-(7-Bromo-5-formyl-6-methyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-4-chloro-benzenesulfonamide

: 165538-00-1
4-Chloro-N-(5-formyl-6,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide

Guidance literature:: With 1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 110 ℃; for 1h;
DOI:10.1016/S0960-894X(98)00220-0

Reference yield:

: 165537-90-6
6-(4-Chlorophenylsulfonyl)amino-2-oxo-5,6,7,8-tetrahydro-2H-benzo[e]pyran

: 165538-00-1
4-Chloro-N-(5-formyl-6,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: Br₂, AcOH / 12 h / Ambient temperature

2: 70 percent / Heating

3: LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 20 °C

4: 4-benzylpyridinium dichromate / CH₂Cl₂ / 20 °C

5: 80 percent / NMP, Pd(PPh₃)4 / 1 h / 110 °C

With 1-methyl-pyrrolidin-2-one; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; bromine; 4-benzyl-pyridine; dichromate; acetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0960-894X(98)00220-0

Reference yield:

: 210685-04-4
3-Bromo-6-(4-chlorophenylsulfonyl)amino-2-oxo-5,6,7,8-tetrahydro-2H-benzo[e]pyran

: 165538-00-1
4-Chloro-N-(5-formyl-6,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / Heating

2: LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 20 °C

3: 4-benzylpyridinium dichromate / CH₂Cl₂ / 20 °C

4: 80 percent / NMP, Pd(PPh₃)4 / 1 h / 110 °C

With 1-methyl-pyrrolidin-2-one; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; 4-benzyl-pyridine; dichromate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0960-894X(98)00220-0