trans-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide

Base Information

Chemical Name:trans-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide
CAS No.:195812-49-8
Molecular Formula:C₂₃H₂₈F₇N₃O
Molecular Weight:495.484
Hs Code.:

Synonyms:trans-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide

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Technology Process of trans-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide

There total 1 articles about trans-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 67589-88-2
trans-4-propylcyclohexanecarbonyl chloride

: 2-(4-fluorophenyl)-4,5-dihydro-N,1-dimethyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-amine hydrochloride

: 195812-49-8
trans-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide

Guidance literature:: With pyridine; dmap; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1016/S0968-0896(97)00058-8

Reference yield: 96.0%

: 2408-36-8
lithium cyanide

: 195812-49-8
trans-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide

: 195812-53-4,195812-62-5,195812-63-6
trans-N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide

Guidance literature:: With potassium carbonate; potassium iodide; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 135 - 140 ℃;
DOI:10.1016/S0968-0896(97)00058-8

Reference yield:

: 195812-49-8
trans-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide

: (+)-trans-N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-N-methyl-4-propylcyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / KI, K₂CO₃ / dimethylformamide; dimethylsulfoxide / 135 - 140 °C

With potassium carbonate; potassium iodide; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00058-8