3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-N'-hydroxy-1-benzenecarboximidamide

Base Information

Chemical Name:3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-N'-hydroxy-1-benzenecarboximidamide
CAS No.:1428760-86-4
Molecular Formula:C₁₇H₁₆ClN₅O₂S
Molecular Weight:389.865
Hs Code.:

Synonyms:3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-N'-hydroxy-1-benzenecarboximidamide

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Chemical Property of 3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-N'-hydroxy-1-benzenecarboximidamide

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Technology Process of 3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-N'-hydroxy-1-benzenecarboximidamide

There total 9 articles about 3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-N'-hydroxy-1-benzenecarboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1428760-85-3
3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]benzonitrile

: 1428760-86-4
3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-N'-hydroxy-1-benzenecarboximidamide

Guidance literature:: With hydroxylamine hydrochloride; potassium tert-butylate; In dimethyl sulfoxide; at 5 - 20 ℃;

Reference yield:

: 59748-90-2
4-Bromo-2-chloro-benzoic Acid

: 1428760-86-4
3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-N'-hydroxy-1-benzenecarboximidamide

Guidance literature:: Multi-step reaction with 9 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -15 °C

2: sodium tetrahydroborate; water / tetrahydrofuran / 1 h / -5 - 0 °C

3: phosphorus tribromide / 1,2-dichloro-ethane / 0.67 h / 0 - 10 °C

4: tetrabutyl-ammonium chloride / water; 1,2-dichloro-ethane / 4 h / 20 °C

5: sodium hydroxide / 4 h / Reflux

6: thionyl chloride / 1 h / Reflux

7: ISOPROPYLAMIDE; caesium carbonate / 2 h / 100 °C

8: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere

9: hydroxylamine hydrochloride; potassium tert-butylate / dimethyl sulfoxide / 5 - 20 °C

With 4-methyl-morpholine; 1,1'-bis-(diphenylphosphino)ferrocene; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; ISOPROPYLAMIDE; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutyl-ammonium chloride; water; phosphorus tribromide; caesium carbonate; sodium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 89720-77-4
4-bromo-1-bromomethyl-2-chlorobenzene

: 1428760-86-4
3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-N'-hydroxy-1-benzenecarboximidamide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrabutyl-ammonium chloride / water; 1,2-dichloro-ethane / 4 h / 20 °C

2: sodium hydroxide / 4 h / Reflux

3: thionyl chloride / 1 h / Reflux

4: ISOPROPYLAMIDE; caesium carbonate / 2 h / 100 °C

5: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere

6: hydroxylamine hydrochloride; potassium tert-butylate / dimethyl sulfoxide / 5 - 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; ISOPROPYLAMIDE; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutyl-ammonium chloride; caesium carbonate; sodium hydroxide; In water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;