(5R,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

Base Information

Chemical Name:(5R,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene
CAS No.:203190-45-8
Molecular Formula:C₂₀H₂₉NO
Molecular Weight:299.456
Hs Code.:

Synonyms:(5R,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

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Technology Process of (5R,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

There total 2 articles about (5R,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 203190-42-5
N-allyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

: 350508-53-1
(2S,4aS,7R,8aR)-4,4,7-trimethyl-2-phenyl-octahydro-benz[e][1,3]oxazine

: 203190-45-8
(5R,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

: (5S,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

Guidance literature:: N-allyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine; With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 13h; Heating;

With potassium fluoride; In diethyl ether; water; at 20 ℃; for 4h;

With silica gel; In hexane; ethyl acetate;
DOI:10.1016/S0040-4020(01)00274-5

Reference yield:

: 203190-42-5
N-allyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

: (2S,4aS,7R,8aR)-4,4,7-Trimethyl-2-phenyl-3-((E)-propenyl)-octahydro-benzo[e][1,3]oxazine

: 203190-45-8
(5R,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

: (5S,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 13h; Heating;
DOI:10.1016/S0040-4020(01)00274-5

Reference yield:

: 203190-45-8
(5R,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

: 350508-37-1
(1R,2S,5R)-5-Methyl-2-[1-methyl-1-((R)-4-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-cyclohexanol

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4020(01)00274-5