(S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Base Information

Chemical Name:(S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone
CAS No.:111266-02-5
Molecular Formula:C₁₂H₁₄O₄
Molecular Weight:222.241
Hs Code.:

Synonyms:(S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Suppliers and Price of (S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

There total 10 articles about (S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1135-24-6,537-98-4
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

: 111266-02-5
(S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; hydrogen / 10percent Pd/C / H₂O / 12 h / 20 °C / 22502.3 Torr

2.1: H₂SO₄ / Heating

3.1: imidazole / dimethylformamide / 0 - 20 °C

4.1: 3.4 g / LiAlH₄ / tetrahydrofuran / 2 h

5.1: triethylamine / CH₂Cl₂ / 0 - 20 °C

5.2: triethylamine; methanesulfonyl azide / CH₂Cl₂

6.1: 1.6 g / lithium hydroxide hydrate / tetrahydrofuran; H₂O / 0 - 20 °C

7.1: Rh₂(5R-MEPY)4 / CH₂Cl₂ / 5 h / Heating

8.1: tetra-n-butylammonium fluoride / 0.33 h / 0 °C

With 1H-imidazole; lithium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; triethylamine; Rh₂(5R-MEPY)4; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo016220s

Reference yield:

: 1135-23-5
3-(4-hydroxy-3-methoxyphenyl)propionic acid

: 111266-02-5
(S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂SO₄ / Heating

2.1: imidazole / dimethylformamide / 0 - 20 °C

3.1: 3.4 g / LiAlH₄ / tetrahydrofuran / 2 h

4.1: triethylamine / CH₂Cl₂ / 0 - 20 °C

4.2: triethylamine; methanesulfonyl azide / CH₂Cl₂

5.1: 1.6 g / lithium hydroxide hydrate / tetrahydrofuran; H₂O / 0 - 20 °C

6.1: Rh₂(5R-MEPY)4 / CH₂Cl₂ / 5 h / Heating

7.1: tetra-n-butylammonium fluoride / 0.33 h / 0 °C

With 1H-imidazole; lithium hydroxide; lithium aluminium tetrahydride; sulfuric acid; tetrabutyl ammonium fluoride; triethylamine; Rh₂(5R-MEPY)4; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo016220s

Reference yield:

: 56024-44-3
methyl 3-(4-hydroxy-3-methoxyphenyl)propanoate

: 111266-02-5
(S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: imidazole / dimethylformamide / 0 - 20 °C

2.1: 3.4 g / LiAlH₄ / tetrahydrofuran / 2 h

3.1: triethylamine / CH₂Cl₂ / 0 - 20 °C

3.2: triethylamine; methanesulfonyl azide / CH₂Cl₂

4.1: 1.6 g / lithium hydroxide hydrate / tetrahydrofuran; H₂O / 0 - 20 °C

5.1: Rh₂(5R-MEPY)4 / CH₂Cl₂ / 5 h / Heating

6.1: tetra-n-butylammonium fluoride / 0.33 h / 0 °C

With 1H-imidazole; lithium hydroxide; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; triethylamine; Rh₂(5R-MEPY)4; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo016220s