O-benzoyl-O-demethylcolchicine

Base Information

• Chemical Name: O-benzoyl-O-demethylcolchicine
• CAS No.: 14686-56-7
• Molecular Formula: C₂₈H₂₇NO₇
• Molecular Weight: 489.525
• Mol file: 14686-56-7.mol

Synonyms:O-benzoyl-O-demethylcolchicine

Chemical Property of O-benzoyl-O-demethylcolchicine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-benzoyl-O-demethylcolchicine

There total 2 articles about O-benzoyl-O-demethylcolchicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

colchiceine (477-27-0,1990-46-1) + benzoyl chloride (98-88-4) → O-benzoyl-O-demethylcolchicine (14686-56-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24.5h;

DOI:10.3390/molecules25051180

Reference yield:

colchicine (64-86-8,54192-66-4) → O-benzoyl-O-demethylcolchicine (14686-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; hydrogenchloride / water / 6 h / 100 °C

2: triethylamine / dichloromethane / 24.5 h / 0 - 20 °C

With hydrogenchloride; acetic acid; triethylamine; In dichloromethane; water;

DOI:10.3390/molecules25051180

upstream raw materials:

colchiceine

benzoyl chloride

colchicine