phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate

Base Information

Chemical Name:phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate
CAS No.:1333489-01-2
Molecular Formula:C₂₀H₁₆FN₃O₄
Molecular Weight:384.339
Hs Code.:

phenyl 2-fluoro-4-(2-((methyl-d<SUB>3</SUB>)carbamoyl)pyridin-4-yloxy)phenylcarbamate

Synonyms:phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate

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Chemical Property of phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate

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Technology Process of phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate

There total 6 articles about phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1257864-28-0
4-(4-amino-3-fluorophenoxy)-N-(methyl-d₃)picolinamide

: 1885-14-9
phenyl chloroformate

: 1333489-01-2
phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 5470-22-4
4-chloropicolinic acid

: 1333489-01-2
phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.33 h / 0 - 20 °C

2.2: 0.5 h / 100 °C

3.1: pyridine / dichloromethane / 1 h / 20 °C

With pyridine; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 24484-93-3
4-Chloro-pyridine-2-carboxylic acid methyl ester

: 1333489-01-2
phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 20 h / 20 °C

2.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.33 h / 0 - 20 °C

2.2: 0.5 h / 100 °C

3.1: pyridine / dichloromethane / 1 h / 20 °C

With pyridine; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;