(1R,2S,6S)-1,6-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:(1R,2S,6S)-1,6-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester
CAS No.:147728-51-6
Molecular Formula:C₁₂H₂₀O₄
Molecular Weight:228.288
Hs Code.:

Synonyms:(1R,2S,6S)-1,6-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester

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Chemical Property of (1R,2S,6S)-1,6-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester

Chemical Property:

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Technology Process of (1R,2S,6S)-1,6-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester

There total 5 articles about (1R,2S,6S)-1,6-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 98540-06-8,122564-88-9
(1R,2S,6S)-1,6-dimethylcyclohexane-1,2-dicarboxylic acid

: 147728-51-6
(1R,2S,6S)-1,6-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: In diethyl ether; at 20 ℃;
DOI:10.1021/ja0208456

Reference yield:

: 1759-64-4
1,6-dimethyl-1-cyclohexene

: 147728-51-6
(1R,2S,6S)-1,6-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / Zn-Cu; POCl₃ / diethyl ether / 16 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: Ac₂O / tetrahydrofuran; hexane / 1.5 h / 20 °C

2.3: 93 percent / RuO₂; NaIO₄ / acetonitrile; CCl₄; H₂O / 14 h / 20 °C

3.1: 100 percent / diethyl ether / 20 °C

With n-butyllithium; copper; zinc; trichlorophosphate; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ja0208456

Reference yield:

: 1502-24-5
2,3-dimethylcyclohexan-1-ol

: 147728-51-6
(1R,2S,6S)-1,6-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Ca(OCl)2

1.2: 78 percent / SO₂Cl₂

2.1: NaBH₄

2.2: 65 percent / Cr(ClO₄)2

3.1: 80 percent / Zn-Cu; POCl₃ / diethyl ether / 16 h / 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

4.2: Ac₂O / tetrahydrofuran; hexane / 1.5 h / 20 °C

4.3: 93 percent / RuO₂; NaIO₄ / acetonitrile; CCl₄; H₂O / 14 h / 20 °C

5.1: 100 percent / diethyl ether / 20 °C

With sodium tetrahydroborate; calcium hypochlorite; n-butyllithium; copper; zinc; trichlorophosphate; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ja0208456