2,8-DIAZA-SPIRO[4.5]DECANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 2,8-DIAZA-SPIRO[4.5]DECANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 336191-17-4
• Molecular Formula: C13H24N2O2
• Molecular Weight: 240.346
• Hs Code.: 29339900
• Mol file: 336191-17-4.mol

Synonyms:2,8-Diazaspiro[4.5]decane-2-carboxylicacid tert-butyl ester;2,8-Diazaspiro[4.5]decane-2-carboxylic acid tert-butylester;

Chemical Property of 2,8-DIAZA-SPIRO[4.5]DECANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.000108mmHg at 25°C
• Refractive Index: 1.514
• Boiling Point: 337 °C at 760 mmHg
• PKA: 10.97±0.20(Predicted)
• Flash Point: 157.6 °C
• PSA: 41.57000
• Density: 1.07 g/cm³
• LogP: 2.26370
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

≥99% ^*data from raw suppliers

2,8-Diaza-spiro[4.5]decane-2-carboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

• Statements: 20-22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,8-DIAZA-SPIRO[4.5]DECANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 12 articles about 2,8-DIAZA-SPIRO[4.5]DECANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

C21H30N2O4 (929301-98-4) → tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate (336191-17-4)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In methanol; at 20 ℃; under 760 Torr;

Reference yield:

8-benzyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester (336191-16-3) → tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate (336191-17-4)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; under 5171.48 Torr;

DOI:10.1016/S0960-894X(02)00095-1

Reference yield:

8-benzyl-2,8-diazaspiro[4.5]decane (336191-15-2) → tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate (336191-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / dioxane

2: H₂ / Pd(OH)2/C / methanol / 5171.48 Torr

With sodium hydroxide; hydrogen; palladium dihydroxide; In 1,4-dioxane; methanol;

DOI:10.1016/S0960-894X(02)00095-1

upstream raw materials:

8-benzyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester

8-benzyl-2-oxa-8-aza-spiro[4.5]decane-1,3-dione

1-phenylmethyl-4-piperidone

ethyl 2-(1-benzylpiperidin-4-ylidene)-2-cyanoacetate

Downstream raw materials:

8-cyclobutyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester

8-acetyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester

8-methane sulfonyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester

2-[3-(3-chlorophenyl)-7-(2,8-diazaspiro[4.5]dec-8-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide