336191-16-3

Basic information

• Product Name: tert-Butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate
• Synonyms: tert-Butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate;8-Benzyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester;2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(phenylMethyl)-, 1,1-diMethylethyl ester
• CAS NO: 336191-16-3
• Molecular Formula: C₂₀H₃₀N₂O₂
• Molecular Weight: 344.496
• Mol File: 336191-16-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 428.9°C at 760 mmHg
• Flash Point: 213.2°C
• Appearance: /
• Density: 1.10
• Vapor Pressure: 1.47E-07mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-Butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate(336191-16-3)
• EPA Substance Registry System: tert-Butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate(336191-16-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 336191-16-3(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate is a synthetic compound with a complex chemical structure. It is a tetracyclic compound containing a spirocyclic ring system, a carboxylic ester group, and a benzyl moiety. The tert-butyl substituent on the nitrogen atom of the spirocyclic ring provides steric hindrance and contributes to the overall stability of the molecule. tert-Butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate may have potential pharmaceutical applications due to its unique structure and properties, but further research is needed to determine its specific uses and potential biological activities.

InChI:InChI=1/C20H30N2O2/c1-19(2,3)24-18(23)22-14-11-20(16-22)9-12-21(13-10-20)15-17-7-5-4-6-8-17/h4-8H,9-16H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 336191-15-2 8-benzyl-2,8-diazaspiro[4.5]decane 
• 336191-13-0 8-benzyl-2-(4-methoxy-benzyl)-2,8-diaza-spiro[4.5]decane-1,3-dione 
• 336191-14-1 8-benzyl-2-(4-methoxybenzyl)-2,8-diazaspiro[4.5]decane 
• 86945-27-9 1-benzyl-4-cyanomethylpiperidine-4-carbonitrile 
• 40117-92-8 1-benzyl-4-carboxymethyl-piperidine-4-carboxylic acid 
• 1463-52-1 ethyl 2-(1-benzylpiperidin-4-ylidene)-2-cyanoacetate 

Downstream Products

• 1001054-52-9 8-cyclobutyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester 
• 959640-90-5 8-cyclobutyl-2,8-diaza-spiro[4.5]decane 
• 336191-17-4 tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate 

Relevant articles and documents

SUBSTITUTED AZASPIRO DERIVATIVES

Substituted azaspiro derivatives of the Formula:are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF

The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents -(CH2)t-O- or -(CH2)r-S-, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is -(CH2)j- or -CH=CH-, j is 1 or 2; p is 1 or 2, or Y is -(CH2)f-, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: Synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes

The synthesis and biological activity of analogues containing spiro piperidinylpyridine and pyrrolidinylpyridine templates are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spiro structures as central template for nonpeptide RGD mimics.