(2S)-2-endo-(methoxycarbonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene

Base Information

• Chemical Name: (2S)-2-endo-(methoxycarbonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene
• CAS No.: 136030-82-5
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.272
• Mol file: 136030-82-5.mol

Synonyms:(2S)-2-endo-(methoxycarbonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene

Chemical Property of (2S)-2-endo-(methoxycarbonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (2S)-2-endo-(methoxycarbonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene

There total 1 articles about (2S)-2-endo-(methoxycarbonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(1S,2S,4S)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (120-74-1,934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7) + L-alanine methyl ester hydrochloride (2491-20-5) → (2S)-2-endo-(methoxycarbonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene (136030-82-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1039/b301980b

Reference yield: 70.0%

(2S)-2-endo-(methoxycarbonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene (136030-82-5) + di-tert-butyl (8S)-8β-(benzyloxycarbonylmethylcarbamoyl)-4-oxa-(1α,2β,3α,5α,6β,7α)-tetracyclo[5.2.1.02,6.03,5]decane-3,5-dicarboxylate (634893-98-4) → di-tert-butyl (4S,11S)-4β-(benzyloxycarbonylmethylcarbamoyl)-11β-(1-methoxycarbonylethylcarbamoyl)-16-oxa-(1α,2β,3α,6α,7β,8α,9β,10α,13α,14β)-hexacyclo[6.6.1.14,6.110,13.02,7.09,14]heptadeca-1,8-dicarboxylate (634893-99-5)

Guidance literature:

In dichloromethane; at 130 ℃; for 12h;

DOI:10.1039/b301980b

upstream raw materials:

(1S,2S,4S)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

L-alanine methyl ester hydrochloride

Downstream raw materials:

di-tert-butyl (4S,11S)-4β-(benzyloxycarbonylmethylcarbamoyl)-11β-(1-methoxycarbonylethylcarbamoyl)-16-oxa-(1α,2β,3α,6α,7β,8α,9β,10α,13α,14β)-hexacyclo[6.6.1.1^4,6.1^10,13.0^2,7.0^9,14]heptadeca-1,8-dicarboxylate