N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-phenylalanine phenylmethyl ester

Base Information

Chemical Name:N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-phenylalanine phenylmethyl ester
CAS No.:220877-46-3
Molecular Formula:C₃₆H₃₆N₂O₆
Molecular Weight:592.692
Hs Code.:

Synonyms:N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-phenylalanine phenylmethyl ester

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Chemical Property of N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-phenylalanine phenylmethyl ester

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Technology Process of N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-phenylalanine phenylmethyl ester

There total 1 articles about N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-phenylalanine phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 100-39-0
benzyl bromide

: 114346-31-5,173054-11-0
(S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

: 220877-46-3
N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-phenylalanine phenylmethyl ester

Guidance literature:: With potassium hydrogencarbonate; In N,N-dimethyl-formamide; for 18h;
DOI:10.1016/S0960-894X(00)00582-5

Reference yield: 98.0%

: 220877-46-3
N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-phenylalanine phenylmethyl ester

: 2-amino-3-[4-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-propionic acid benzyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;
DOI:10.1016/S0960-894X(00)00582-5

Reference yield:

: 220877-46-3
N-[(1,1-dimethylethoxy)carbonyl]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-phenylalanine phenylmethyl ester

: (S)-3-{4-[3-(4-Acetoxy-phenyl)-2,5-dioxo-pyrrolidin-1-yl]-phenyl}-2-[((S)-1-benzyl-5-oxo-pyrrolidine-2-carbonyl)-amino]-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / 4 N aq. HCl / dioxane

2: 95 percent / HBTU; DIPEA / dimethylformamide

3: 64 percent / Et₂NH / dimethylformamide

4: carbonyl diimidazole / CH₂Cl₂

5: H₂ / Pd/C

With hydrogenchloride; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(00)00582-5