tert-butyl (2-(2-((6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)ethoxy)ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-(2-((6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)ethoxy)ethyl)carbamate
CAS No.:1432910-03-6
Molecular Formula:C₂₉H₃₄ClN₇O₄
Molecular Weight:580.086
Hs Code.:

Synonyms:tert-butyl (2-(2-((6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)ethoxy)ethyl)carbamate

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Chemical Property of tert-butyl (2-(2-((6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)ethoxy)ethyl)carbamate

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Technology Process of tert-butyl (2-(2-((6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)ethoxy)ethyl)carbamate

There total 5 articles about tert-butyl (2-(2-((6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)ethoxy)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432910-07-0
C₂₁H₁₈ClN₅O₂S

: 127828-22-2
tert-butyl 2-(2-aminoethoxy)ethylcarbamate

: 1432910-03-6
tert-butyl (2-(2-((6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)ethoxy)ethyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 139115-91-6
2-(2-tert-butyloxycarbonylaminoethoxy)ethanol

: 1432910-03-6
tert-butyl (2-(2-((6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)ethoxy)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 302331-20-0
methanesulfonic acid 2-(2-tert-butoxycarbonylamino-ethoxy)-ethyl ester

: 1432910-03-6
tert-butyl (2-(2-((6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)ethoxy)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;