2-(3-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone

Base Information

Chemical Name:2-(3-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone
CAS No.:1428968-74-4
Molecular Formula:C₂₂H₁₈FN₃O₂
Molecular Weight:375.402
Hs Code.:

Synonyms:2-(3-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone

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Chemical Property of 2-(3-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone

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Technology Process of 2-(3-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone

There total 3 articles about 2-(3-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 57476-50-3
1-tert-butoxycarbonyl-3-formylindole

: 1428972-51-3
N-(3-fluorobenzylidene)-2-methoxypyridin-4-amine

: 1428968-74-4
2-(3-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone

Guidance literature:: With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; triethylamine; In ethanol; at 70 - 160 ℃; for 72h; Sealed tube; Microwave irradiation;

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 1428968-74-4
2-(3-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / acetonitrile / 20 °C

2: triethylamine; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride / ethanol / 72 h / 70 - 160 °C / Sealed tube; Microwave irradiation

With dmap; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; triethylamine; In ethanol; acetonitrile;

Reference yield:

: 20265-39-8
4-amino-2-methoxypyridine

: 456-48-4
3-Fluorobenzaldehyde

: 1428968-74-4
2-(3-fluorophenyl)-1-(1H-indol-3-yl)-2-((2-methoxypyridin-4-yl)amino)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium sulfate / ethanol / 80 °C

2: triethylamine; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride / ethanol / 72 h / 70 - 160 °C / Sealed tube; Microwave irradiation

With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; magnesium sulfate; triethylamine; In ethanol;