N,N'-(4-fluoro-1,2-phenylene)bis(4-methylbenzenesulfonamide)

Base Information

• Chemical Name: N,N'-(4-fluoro-1,2-phenylene)bis(4-methylbenzenesulfonamide)
• CAS No.: 113269-02-6
• Molecular Formula: C₂₀H₁₉FN₂O₄S₂
• Molecular Weight: 434.512
• Mol file: 113269-02-6.mol

Synonyms:N,N'-(4-fluoro-1,2-phenylene)bis(4-methylbenzenesulfonamide)

Chemical Property of N,N'-(4-fluoro-1,2-phenylene)bis(4-methylbenzenesulfonamide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N'-(4-fluoro-1,2-phenylene)bis(4-methylbenzenesulfonamide)

There total 1 articles about N,N'-(4-fluoro-1,2-phenylene)bis(4-methylbenzenesulfonamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-4-fluoroaniline (364-78-3) → N,N'-(4-fluoro-1,2-phenylene)bis(4-methylbenzenesulfonamide) (113269-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 50percent aq. phosphinic acid / 10percent Pd/C / methanol / 0.33 h / Heating

2: 95 percent / pyridine / 18 h / 85 °C

With pyridine; hypophosphorous acid; palladium on activated charcoal; In methanol;

DOI:10.3987/R-1987-09-2433

Reference yield: 96.0%

N,N'-(4-fluoro-1,2-phenylene)bis(4-methylbenzenesulfonamide) (113269-02-6) + 1,2-bis(methylene)cyclohexane (2819-48-9) → 2-fluoro-5,12-ditosyl-5,6,7,8,9,10,11,12-octahydrodibenzo[b,f][1,4]diazocine

Guidance literature:

With oxygen; palladium diacetate; potassium iodide; In acetonitrile; at 70 ℃; for 24h; under 7600.51 Torr; regioselective reaction; Molecular sieve;

DOI:10.1016/j.tetlet.2017.05.053

Reference yield: 70.0%

N,N'-(4-fluoro-1,2-phenylene)bis(4-methylbenzenesulfonamide) (113269-02-6) → 4-fluoro-5-nitro-1,2-di(4-methylbenzenesulfonylamino)benzene (113269-03-7)

Guidance literature:

With nitric acid; acetic acid; for 0.666667h;

DOI:10.3987/R-1987-09-2433

upstream raw materials:

2-nitro-4-fluoroaniline

Downstream raw materials:

4-fluoro-5-nitro-1,2-di(4-methylbenzenesulfonylamino)benzene

6-fluoro-7-nitroquinoxaline

4-fluoro-5-nitrobenzene-1,2-diamine