(2S,3S,5S)-2-hexyl-5-hydroxy-3-[(triisopropylsilyl)oxy]hexadecanoic acid phenylmethyl ester

Base Information

Chemical Name:(2S,3S,5S)-2-hexyl-5-hydroxy-3-[(triisopropylsilyl)oxy]hexadecanoic acid phenylmethyl ester
CAS No.:1072902-82-9
Molecular Formula:C₃₈H₇₀O₄Si
Molecular Weight:619.057
Hs Code.:

Synonyms:(2S,3S,5S)-2-hexyl-5-hydroxy-3-[(triisopropylsilyl)oxy]hexadecanoic acid phenylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,5S)-2-hexyl-5-hydroxy-3-[(triisopropylsilyl)oxy]hexadecanoic acid phenylmethyl ester

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Technology Process of (2S,3S,5S)-2-hexyl-5-hydroxy-3-[(triisopropylsilyl)oxy]hexadecanoic acid phenylmethyl ester

There total 5 articles about (2S,3S,5S)-2-hexyl-5-hydroxy-3-[(triisopropylsilyl)oxy]hexadecanoic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: (2S,3S,5S)-3,5-dihydroxy-2-hexylhexadecanoic acid phenylmethyl ester

: 1072902-82-9
(2S,3S,5S)-2-hexyl-5-hydroxy-3-[(triisopropylsilyl)oxy]hexadecanoic acid phenylmethyl ester

Guidance literature:: With 2,4,6-trimethyl-pyridine; In dichloromethane; at -78 ℃; for 3h; Inert atmosphere;

Reference yield: 73.5%

: (2S,3S,5S)-3,5-dihydroxy-2-hexylhexadecanoic acid phenylmethyl ester

: 1072902-82-9
(2S,3S,5S)-2-hexyl-5-hydroxy-3-[(triisopropylsilyl)oxy]hexadecanoic acid phenylmethyl ester

Guidance literature:: With 2,4,6-trimethyl-pyridine; triisopropylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2021.113358

Reference yield:

: 104872-04-0,104872-27-7,104872-28-8,111466-61-6,111466-62-7,111466-63-8,130193-40-7,130193-41-8,130193-42-9,130193-43-0,96829-58-2,1225451-00-2
Orlistat

: 1072902-82-9
(2S,3S,5S)-2-hexyl-5-hydroxy-3-[(triisopropylsilyl)oxy]hexadecanoic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol; water / 1 h / 20 °C

2: N,N-dimethyl-formamide / 20 °C

3: 2,4,6-trimethyl-pyridine; triisopropylsilyl trifluoromethanesulfonate / dichloromethane / -78 °C / Inert atmosphere

With 2,4,6-trimethyl-pyridine; triisopropylsilyl trifluoromethanesulfonate; potassium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113358