6-(4,4-difluoro-1-phenylcyclohexylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Base Information

Chemical Name:6-(4,4-difluoro-1-phenylcyclohexylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione
CAS No.:1616922-12-3
Molecular Formula:C₂₃H₂₇F₂N₃O₃
Molecular Weight:431.482
Hs Code.:

Synonyms:6-(4,4-difluoro-1-phenylcyclohexylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

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Chemical Property of 6-(4,4-difluoro-1-phenylcyclohexylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

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Technology Process of 6-(4,4-difluoro-1-phenylcyclohexylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

There total 13 articles about 6-(4,4-difluoro-1-phenylcyclohexylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616924-52-7
9-benzyloxy-6-(4,4-difluoro-1-phenylcyclohexylmethyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

: 1616922-12-3
6-(4,4-difluoro-1-phenylcyclohexylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 60356-11-8
cyano(1,4-dioxaspiro[4.5]dec-8-ylidene)acetic acid ethyl ester

: 1616922-12-3
6-(4,4-difluoro-1-phenylcyclohexylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: Multi-step reaction with 12 steps

1.1: copper(l) iodide / tetrahydrofuran; dibutyl ether / 2 h / -78 - -30 °C

1.2: 1 h / -78 - -30 °C

2.1: sodium iodide / dimethyl sulfoxide / 3 h / 150 °C / Sealed tube

2.2: 16 h / 20 °C

3.1: hydroxylamine / ethanol; water / 16 h / 60 °C

4.1: 16 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

6.1: sodium methylate / methanol / 16 h / 0 - 20 °C

7.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / Reflux

8.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 20 °C

9.1: hydrogenchloride / tetrahydrofuran; water / 7 h / 20 °C

10.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 0.5 h / 20 °C

11.1: dimethylaminosulphur trifluoride / dichloromethane / 3 h / 0 - 20 °C

12.1: hydrogen; palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; lithium hydroxide monohydrate; dimethylaminosulphur trifluoride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; dibutyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1265624-85-8
cyano(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetic acid ethyl ester

: 1616922-12-3
6-(4,4-difluoro-1-phenylcyclohexylmethyl)-9-hydroxy-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium iodide / dimethyl sulfoxide / 3 h / 150 °C / Sealed tube

1.2: 16 h / 20 °C

2.1: hydroxylamine / ethanol; water / 16 h / 60 °C

3.1: 16 h / 20 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

5.1: sodium methylate / methanol / 16 h / 0 - 20 °C

6.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / Reflux

7.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 20 °C

8.1: hydrogenchloride / tetrahydrofuran; water / 7 h / 20 °C

9.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 0.5 h / 20 °C

10.1: dimethylaminosulphur trifluoride / dichloromethane / 3 h / 0 - 20 °C

11.1: hydrogen; palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; lithium hydroxide monohydrate; dimethylaminosulphur trifluoride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;