5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

Base Information

Chemical Name:5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide
CAS No.:1616924-49-2
Molecular Formula:C₃₈H₅₃N₃O₆Si
Molecular Weight:675.941
Hs Code.:

5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

Synonyms:5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

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Chemical Property of 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

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Technology Process of 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

There total 9 articles about 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.85%

: N-(2-((tert-butyldimethylsilyl)oxy)ethyl)propan-2-amine

: 1616924-48-1
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid

: 1616924-49-2
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

Reference yield:

: 60356-11-8
cyano(1,4-dioxaspiro[4.5]dec-8-ylidene)acetic acid ethyl ester

: 1616924-49-2
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper(l) iodide / tetrahydrofuran; dibutyl ether / 2 h / -78 - -30 °C

1.2: 1 h / -78 - -30 °C

2.1: sodium iodide / dimethyl sulfoxide / 3 h / 150 °C / Sealed tube

2.2: 16 h / 20 °C

3.1: hydroxylamine / ethanol; water / 16 h / 60 °C

4.1: 16 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

6.1: sodium methylate / methanol / 16 h / 0 - 20 °C

7.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / Reflux

8.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium methylate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium iodide; In tetrahydrofuran; methanol; ethanol; dibutyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1616924-49-2
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid; ammonium acetate / toluene / 16 h / Dean-Stark; Reflux

2.1: copper(l) iodide / tetrahydrofuran; dibutyl ether / 2 h / -78 - -30 °C

2.2: 1 h / -78 - -30 °C

3.1: sodium iodide / dimethyl sulfoxide / 3 h / 150 °C / Sealed tube

3.2: 16 h / 20 °C

4.1: hydroxylamine / ethanol; water / 16 h / 60 °C

5.1: 16 h / 20 °C

6.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

7.1: sodium methylate / methanol / 16 h / 0 - 20 °C

8.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / Reflux

9.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; palladium 10% on activated carbon; ammonium acetate; hydrogen; hydroxylamine; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium iodide; In tetrahydrofuran; methanol; ethanol; dibutyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;