7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-hydroxy-3-methylphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Base Information

Chemical Name:7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-hydroxy-3-methylphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:1276544-72-9
Molecular Formula:C₂₃H₁₇Cl₂FN₂O₂
Molecular Weight:443.305
Hs Code.:

Synonyms:7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-hydroxy-3-methylphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of 7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-hydroxy-3-methylphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of 7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-hydroxy-3-methylphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 5 articles about 7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-hydroxy-3-methylphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276544-74-1
7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1276544-72-9
7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-hydroxy-3-methylphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: 7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one; With boron tribromide; In dichloromethane; at 20 ℃; for 4h;

With methanol;

Reference yield:

: 896729-45-6
6-Chloro-1-(4-methoxybenzyl)-1H-benzo[d][1,3]oxazine-2,4-dione

: 1276544-72-9
7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-hydroxy-3-methylphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 8 h / 130 °C

2: trichlorophosphate; N,N-dimethyl-aniline / toluene / 5 h / 90 °C

3: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

4: lithium chloride; cesiumhydroxide monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 160 °C / Inert atmosphere; CEM Discover microwave reactor

5: boron tribromide / dichloromethane / 4 h / 20 °C

With cesiumhydroxide monohydrate; potassium tert-butylate; boron tribromide; acetic acid; N,N-dimethyl-aniline; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; 4: Suzuki Coupling;

Reference yield:

: 1059065-37-0
7-Chloro-1-(4-methoxybenzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

: 1276544-72-9
7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-hydroxy-3-methylphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 5 h / 90 °C

2: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3: lithium chloride; cesiumhydroxide monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 160 °C / Inert atmosphere; CEM Discover microwave reactor

4: boron tribromide / dichloromethane / 4 h / 20 °C

With cesiumhydroxide monohydrate; potassium tert-butylate; boron tribromide; N,N-dimethyl-aniline; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; 3: Suzuki Coupling;