7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Base Information

Chemical Name:7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:1276544-74-1
Molecular Formula:C₃₂H₂₇Cl₂FN₂O₃
Molecular Weight:577.482
Hs Code.:

Synonyms:7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of 7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of 7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 6 articles about 7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 214360-63-1
2-(3-Methyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1276544-73-0
5,7-dichloro-3-(2-chloro-4-fluorobenzyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1276544-74-1
7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: With cesiumhydroxide monohydrate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 160 ℃; for 0.333333h; Inert atmosphere; CEM Discover microwave reactor;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1276544-74-1
7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 21 h / 20 - 32 °C / Inert atmosphere

2: acetic acid / 8 h / 130 °C

3: trichlorophosphate; N,N-dimethyl-aniline / toluene / 5 h / 90 °C

4: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

5: lithium chloride; cesiumhydroxide monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 160 °C / Inert atmosphere; CEM Discover microwave reactor

With cesiumhydroxide monohydrate; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; N,N-dimethyl-aniline; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; toluene; 5: Suzuki Coupling;

Reference yield:

: 896729-45-6
6-Chloro-1-(4-methoxybenzyl)-1H-benzo[d][1,3]oxazine-2,4-dione

: 1276544-74-1
7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 8 h / 130 °C

2: trichlorophosphate; N,N-dimethyl-aniline / toluene / 5 h / 90 °C

3: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

4: lithium chloride; cesiumhydroxide monohydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 160 °C / Inert atmosphere; CEM Discover microwave reactor

With cesiumhydroxide monohydrate; potassium tert-butylate; acetic acid; N,N-dimethyl-aniline; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; toluene; 4: Suzuki Coupling;