3-PyridinecarboxaMide, 2-chloro-N-[4-(1-cyanocyclopentyl)phenyl]

Base Information

Chemical Name:3-PyridinecarboxaMide, 2-chloro-N-[4-(1-cyanocyclopentyl)phenyl]
CAS No.:1158560-99-6
Molecular Formula:C₁₈H₁₆ClN₃O
Molecular Weight:325.798
Hs Code.:
Mol file:1158560-99-6.mol

Synonyms:N-[4-(1-cyanocyclopentyl)phenyl][2-chloro(3-pyridyl)]carboxamide

Suppliers and Price of 3-PyridinecarboxaMide, 2-chloro-N-[4-(1-cyanocyclopentyl)phenyl]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide
250mg
$ 1190.00

TRC
2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide
25mg
$ 150.00

Medical Isotopes, Inc.
2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide
250 mg
$ 2200.00

Total 8 raw suppliers

Chemical Property of 3-PyridinecarboxaMide, 2-chloro-N-[4-(1-cyanocyclopentyl)phenyl]

Chemical Property:

Melting Point:155-157°C
Boiling Point:459.7±45.0 °C(Predicted)
PKA:11.00±0.70(Predicted)
Density:1.31±0.1 g/cm3(Predicted)
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide is an intermediate Apatinib 25-N-Oxide (A726160), a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).

Technology Process of 3-PyridinecarboxaMide, 2-chloro-N-[4-(1-cyanocyclopentyl)phenyl]

There total 4 articles about 3-PyridinecarboxaMide, 2-chloro-N-[4-(1-cyanocyclopentyl)phenyl] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2942-59-8
2-chloronicotinic acid

: 115279-73-7
1-(4-aminophenyl)cyclopentane-1-carbonitrile

: 1158560-99-6
N-[4-(1-cyanocyclopentyl)phenyl][2-chloro(3-pyridyl)]carboxamide

Guidance literature:: 2-chloronicotinic acid; With 1,1'-carbonyldiimidazole; In 1,4-dioxane; at 90 ℃; for 2h; Inert atmosphere;

1-(4-aminophenyl)cyclopentane-1-carbonitrile; In 1,4-dioxane; for 6h;

Reference yield:

: 140-29-4
phenylacetonitrile

: 1158560-99-6
N-[4-(1-cyanocyclopentyl)phenyl][2-chloro(3-pyridyl)]carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / 40 - 70 °C / Large scale

2.1: nitric acid; sulfuric acid / 0.67 h / -10 - 0 °C / Large scale

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 760.05 Torr

4.1: 1,1'-carbonyldiimidazole / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

4.2: 6 h

With sulfuric acid; palladium 10% on activated carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; nitric acid; 1,1'-carbonyldiimidazole; sodium hydroxide; In 1,4-dioxane; ethanol;

Reference yield:

: 77-57-6
1-phenyl-1-cyclopentanecarbonitrile

: 1158560-99-6
N-[4-(1-cyanocyclopentyl)phenyl][2-chloro(3-pyridyl)]carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitric acid; sulfuric acid / 0.67 h / -10 - 0 °C / Large scale

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 760.05 Torr

3.1: 1,1'-carbonyldiimidazole / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

3.2: 6 h

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; 1,1'-carbonyldiimidazole; In 1,4-dioxane; ethanol;