8-ethyl-10,12-dimethoxy-1-(phenylmethoxy)-6H-benzonaphtho<1,2-b>pyran-6-one

Base Information

Chemical Name:8-ethyl-10,12-dimethoxy-1-(phenylmethoxy)-6H-benzonaphtho<1,2-b>pyran-6-one
CAS No.:114862-75-8
Molecular Formula:C₂₈H₂₄O₅
Molecular Weight:440.496
Hs Code.:

8-ethyl-10,12-dimethoxy-1-(phenylmethoxy)-6H-benzo<d>naphtho<1,2-b>pyran-6-one

Synonyms:8-ethyl-10,12-dimethoxy-1-(phenylmethoxy)-6H-benzonaphtho<1,2-b>pyran-6-one

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Chemical Property of 8-ethyl-10,12-dimethoxy-1-(phenylmethoxy)-6H-benzonaphtho<1,2-b>pyran-6-one

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Technology Process of 8-ethyl-10,12-dimethoxy-1-(phenylmethoxy)-6H-benzonaphtho<1,2-b>pyran-6-one

There total 13 articles about 8-ethyl-10,12-dimethoxy-1-(phenylmethoxy)-6H-benzonaphtho<1,2-b>pyran-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 133344-07-7
5-Ethyl-2-iodo-3-methoxy-benzoic acid 5-benzyloxy-4-methoxy-naphthalen-1-yl ester

: 114862-75-8
8-ethyl-10,12-dimethoxy-1-(phenylmethoxy)-6H-benzonaphtho<1,2-b>pyran-6-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium acetate; In N,N-dimethyl acetamide; at 130 ℃; for 3h;
DOI:10.1016/S0040-4039(00)97051-5

Reference yield: 77.0%

: 114862-74-7
1-(benzyloxy)-6-oxo-8-ethyl-10-methoxy-12-hydroxy-6H-benzonaphtho<1,2-b>pyran

: 74-88-4
methyl iodide

: 114862-75-8
8-ethyl-10,12-dimethoxy-1-(phenylmethoxy)-6H-benzonaphtho<1,2-b>pyran-6-one

Guidance literature:: With potassium tert-butylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jo00251a008

Reference yield:

: 114862-72-5
8-ethyl-10-methoxy-1-(phenylmethoxy)-6H-benzonaphtho<1,2-b>pyran-6-one

: 114862-75-8
8-ethyl-10,12-dimethoxy-1-(phenylmethoxy)-6H-benzonaphtho<1,2-b>pyran-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide 2.) H₂O, citric acid, Na₂HPO₄, Fremy's salt (K₂ON(SO₃)2) / 1.) ethanol, reflux, 3 h, 2.) RT, overnight

2: 93 percent / sodium dithionite / H₂O; dioxane / 0.5 h / Ambient temperature

3: 77 percent / K₂CO₃, potassium tert-butoxide / dimethylformamide; tetrahydrofuran / Ambient temperature

With disodium hydrogenphosphate; sodium dithionite; potassium tert-butylate; water; potassium carbonate; citric acid; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00251a008