1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3'-fluoro-5-methylbiphenyl-2-yl}ethanamine

Base Information

Chemical Name:1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3'-fluoro-5-methylbiphenyl-2-yl}ethanamine
CAS No.:1382995-52-9
Molecular Formula:C₂₂H₂₅ClFN₃O
Molecular Weight:401.911
Hs Code.:

Synonyms:1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3'-fluoro-5-methylbiphenyl-2-yl}ethanamine

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Chemical Property of 1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3'-fluoro-5-methylbiphenyl-2-yl}ethanamine

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Technology Process of 1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3'-fluoro-5-methylbiphenyl-2-yl}ethanamine

There total 5 articles about 1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3'-fluoro-5-methylbiphenyl-2-yl}ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382995-51-8
1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3'-fluoro-5-methylbiphenyl-2-yl}ethanone

: 1382995-52-9
1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3'-fluoro-5-methylbiphenyl-2-yl}ethanamine

Guidance literature:: With methanol; ammonium acetate; sodium cyanoborohydride; In tetrahydrofuran; acetonitrile; at 65 ℃;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1382995-52-9
1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3'-fluoro-5-methylbiphenyl-2-yl}ethanamine

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / acetic acid / 18 h / 20 °C

2: triethylamine / dichloromethane / -78 - 20 °C

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 80 °C / Inert atmosphere

4: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 80 °C / Inert atmosphere

5: methanol; ammonium acetate; sodium cyanoborohydride / tetrahydrofuran; acetonitrile / 65 °C

With methanol; N-Bromosuccinimide; ammonium acetate; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; acetic acid; toluene; acetonitrile;

Reference yield:

: 1-(3-bromo-5-chloro-2-hydroxy-4-methylphenyl)ethanone

: 1382995-52-9
1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3'-fluoro-5-methylbiphenyl-2-yl}ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / -78 - 20 °C

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 80 °C / Inert atmosphere

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 80 °C / Inert atmosphere

4: methanol; ammonium acetate; sodium cyanoborohydride / tetrahydrofuran; acetonitrile / 65 °C

With methanol; ammonium acetate; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;