5-[(4-bromo-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

Base Information

Chemical Name:5-[(4-bromo-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione
CAS No.:442520-37-8
Molecular Formula:C₁₈H₂₂BrN₃O₄
Molecular Weight:424.294
Hs Code.:

Synonyms:5-[(4-bromo-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

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Chemical Property of 5-[(4-bromo-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

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Technology Process of 5-[(4-bromo-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

There total 6 articles about 5-[(4-bromo-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 109-01-3
1-methyl-piperazine

: 123419-94-3
5-<4-Bromophenylamino(methylthio)methylene>-2,2-dimethyl-4,6-dioxo-1,3-dioxane

: 442520-37-8
5-[(4-bromo-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

Guidance literature:: In chloroform; at 60 ℃; for 8h;
DOI:10.1002/jhet.5570390102

Reference yield:

: 100981-05-3
5-[bis(methylthio)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione

: 442520-37-8
5-[(4-bromo-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: CHCl₃ / Heating

2: N-bromosuccinimide / CH₂Cl₂ / -40 °C

3: 98 percent / CHCl₃ / 8 h / 60 °C

With N-Bromosuccinimide; In dichloromethane; chloroform;
DOI:10.1002/jhet.5570390102

Reference yield:

: 2033-24-1
cycl-isopropylidene malonate

: 442520-37-8
5-[(4-bromo-phenylamino)-(4-methyl-piperazin-1-yl)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / lithium hydride / dimethylsulfoxide / 1 h / 20 °C

2: N-bromosuccinimide / CH₂Cl₂ / -40 °C

3: 98 percent / CHCl₃ / 8 h / 60 °C

With N-Bromosuccinimide; lithium hydride; In dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1002/jhet.5570390102