123419-94-3Relevant articles and documents
Mechanistic studies of a "declick" reaction
Meadows, Margaret K.,Sun, Xiaolong,Kolesnichenko, Igor V.,Hinson, Caroline M.,Johnson, Kenneth A.,Anslyn, Eric V.
, p. 8817 - 8824 (2019/10/16)
A kinetic analysis of a "declick" reaction is described. Compound 1, previously reported to couple an amine and a thiol (i.e. "click") under mild aqueous conditions to create 2, undergoes release of the unaltered coupling partners upon triggering with dit
Convenient synthesis of 5-(arylamino(alkylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-diones and 2-arylthio-4-quinolones
Tang, Jing,Huang, Xian
, p. 140 - 141 (2007/10/03)
Meldrum's acid reacted with an aryl isothiocynate and alkyl halides to afford the 5-(arylamino(alkylthio)methylene)-5-methylthio-2,2-dimethyl-1,3-dioxane-4, 6-diones and the compounds underwent thermal cyclization to give the 4-2-arylthio-4(1H)-quinolones.
Synthesis of 2-amino-1,4-dihydro-4-quinolinones and diaminomethylene Meldrum's acids derivatives as potential potassium channel openers
Erb, Benedicte,Rigo, Benoit,Pirotte, Bernard,Couturier, Daniel
, p. 15 - 28 (2007/10/03)
Starting from 5-bismethylthiomethylene Meldrum's acid, the synthesis of 5-diaminomethylene Meldrum's acids and 2-aminoquinolone derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.