2-ethylbutanoic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-[1,2,4]triazol-3-yloxymethyl ester

Base Information

Chemical Name:2-ethylbutanoic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-[1,2,4]triazol-3-yloxymethyl ester
CAS No.:1350551-36-8
Molecular Formula:C₃₈H₄₇FN₈O₉
Molecular Weight:778.838
Hs Code.:

2-ethylbutanoic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-[1,2,4]triazol-3-yloxymethyl ester

Synonyms:2-ethylbutanoic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-[1,2,4]triazol-3-yloxymethyl ester

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Chemical Property of 2-ethylbutanoic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-[1,2,4]triazol-3-yloxymethyl ester

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Technology Process of 2-ethylbutanoic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-[1,2,4]triazol-3-yloxymethyl ester

There total 6 articles about 2-ethylbutanoic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-[1,2,4]triazol-3-yloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350552-04-3
2-ethylbutanoic acid 5-{(R)-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester

: 64-19-7,77671-22-8
acetic acid

: 1350551-36-8
2-ethylbutanoic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-[1,2,4]triazol-3-yloxymethyl ester

Guidance literature:: With triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; dmap; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 951803-95-5
4-({[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl}amino)benzamidine acetate

: 1350551-36-8
2-ethylbutanoic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-[1,2,4]triazol-3-yloxymethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / N,N-dimethyl-formamide / 20 °C

2: tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate / dichloromethane; water; tetrahydrofuran / -10 - 20 °C

3: sodium iodide; potassium hydrogencarbonate / N,N-dimethyl acetamide / 45 °C

4: SUMICHIRAL OA-2500 / methanol / Resolution of racemate

5: triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate / dmap / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; potassium hydrogencarbonate; triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; sodium iodide; dmap; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;

Reference yield:

: 1350552-03-2
2-ethylbutanoic acid 5-{(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester

: 1350551-36-8
2-ethylbutanoic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2,2-dimethylpropoxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-[1,2,4]triazol-3-yloxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SUMICHIRAL OA-2500 / methanol / Resolution of racemate

2: triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate / dmap / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C

With triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; dmap; In methanol; dichloromethane; N,N-dimethyl-formamide;