S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate

Base Information

• Chemical Name: S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate
• CAS No.: 1440419-50-0
• Molecular Formula: C₃₀H₃₇NO₄S
• Molecular Weight: 507.694
• Mol file: 1440419-50-0.mol

Synonyms:S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate

Chemical Property of S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate

There total 10 articles about S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methylphenyl chlorothioformate (39594-84-8) + N-{[7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl]methyl}-1-(4-methoxyphenyl)methanamine (1440419-49-7) → S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate (1440419-50-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1002/cjoc.202000291

Reference yield: 95.0%

phenyl chlorothioformate (13464-19-2) + N-{[7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl]methyl}-1-(4-methoxyphenyl)methanamine (1440419-49-7) → S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate (1440419-50-0)

Guidance literature:

N-{[7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl]methyl}-1-(4-methoxyphenyl)methanamine; With dmap; triethylamine; In dichloromethane; for 1h;

phenyl chlorothioformate; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/chem.201203203

Reference yield:

3-Ethoxycyclohex-2-en-1-one (5323-87-5) → S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate (1440419-50-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: diethyl ether; tetrahydrofuran / 12 h / 0 - 20 °C

2.1: rac-Pro-OH; 2,5-dimethyl-piperazine / chloroform / 168 h / 50 °C

3.1: 2-iodoxybenzoic acid; 4-methylmorpholine N-oxide / dimethyl sulfoxide / 72 h / 20 - 45 °C

4.1: toluene-4-sulfonic acid / toluene / 24 h / Dean-Stark; Inert atmosphere; Reflux

5.1: lithium aluminium tetrahydride / diethyl ether / 6 h / 0 - 20 °C

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 5 h / 20 °C

7.1: dmap; triethylamine / dichloromethane / 1 h

7.2: 0 - 20 °C

With dmap; lithium aluminium tetrahydride; 2-iodoxybenzoic acid; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; 2,5-dimethyl-piperazine; rac-Pro-OH; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; dimethyl sulfoxide; toluene;

DOI:10.1002/chem.201203203

upstream raw materials:

(hex-5-enyl)magnesium bromide

3-Ethoxycyclohex-2-en-1-one

3-(hex-5-en-1-yl)cyclohex-2-enone

C₁₅H₂₅NO₂

Downstream raw materials:

C₂₈H₃₃NO₃S