N-[1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-1-sulfonylamino)-acetamide

Base Information

Chemical Name:N-[1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-1-sulfonylamino)-acetamide
CAS No.:92771-24-9
Molecular Formula:C₂₇H₂₈N₄O₄S
Molecular Weight:504.61
Hs Code.:

Synonyms:N-[1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-1-sulfonylamino)-acetamide

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Chemical Property of N-[1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-1-sulfonylamino)-acetamide

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Technology Process of N-[1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-1-sulfonylamino)-acetamide

There total 6 articles about N-[1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-1-sulfonylamino)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 110-89-4
piperidine

: 92771-18-1
3-(4-Cyano-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionic acid 4-nitro-phenyl ester

: 92771-24-9
N-[1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-1-sulfonylamino)-acetamide

Guidance literature:: In pyridine; N,N-dimethyl-formamide; for 7h; Ambient temperature;

Reference yield:

: 52117-01-8
N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester

: 92771-24-9
N-[1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-1-sulfonylamino)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH (1 mol/l) / acetic acid; H₂O / pH 3.8-4.0

2: NaOH (1 mol/l) / diethyl ether; ethyl acetate; H₂O / 10 h

3: DCC / pyridine / 12 h / Ambient temperature

4: 40 percent / pyridine; dimethylformamide / 7 h / Ambient temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; In pyridine; diethyl ether; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 92740-47-1
α-naphthylenesulfonylglycine

: 92771-24-9
N-[1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-1-sulfonylamino)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 1 h / Heating

2: NaOH (1 mol/l) / diethyl ether; ethyl acetate; H₂O / 10 h

3: DCC / pyridine / 12 h / Ambient temperature

4: 40 percent / pyridine; dimethylformamide / 7 h / Ambient temperature

With sodium hydroxide; thionyl chloride; dicyclohexyl-carbodiimide; In pyridine; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide;