(S)-(+)-2-phenoxy-1-p-tolylethanol

Base Information

Chemical Name:(S)-(+)-2-phenoxy-1-p-tolylethanol
CAS No.:1158541-00-4
Molecular Formula:C₁₅H₁₆O₂
Molecular Weight:228.291
Hs Code.:

Synonyms:(S)-(+)-2-phenoxy-1-p-tolylethanol

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Chemical Property of (S)-(+)-2-phenoxy-1-p-tolylethanol

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Technology Process of (S)-(+)-2-phenoxy-1-p-tolylethanol

There total 4 articles about (S)-(+)-2-phenoxy-1-p-tolylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 19513-79-2
2-phenoxy-1-p-tolylethanone

: 1158541-00-4
(S)-(+)-2-phenoxy-1-p-tolylethanol

Guidance literature:: 2-phenoxy-1-p-tolylethanone; With 2-[(1,3,2-dioxaborolan-2-yloxy)diphenylmethyl]pyrrolidine; dimethylsulfide borane complex; In tetrahydrofuran; at 25 ℃; for 2h; Inert atmosphere;

With methanol; In tetrahydrofuran; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Cooling with ice;
DOI:10.1021/jo900666r

Reference yield: 88.0%

: 13107-39-6,53631-45-1,86457-69-4,135413-94-4
(S)-4-methylstyrene oxide

: 108-95-2,27073-41-2
phenol

: 1158541-00-4
(S)-(+)-2-phenoxy-1-p-tolylethanol

Guidance literature:: phenol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

(S)-4-methylstyrene oxide; In N,N-dimethyl-formamide; at 60 ℃; for 24h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/jo102294j

Reference yield:

: (S)-2-bromo-1-(4-methylphenyl)ethanol

: 1158541-00-4
(S)-(+)-2-phenoxy-1-p-tolylethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 24 h / 60 °C / Inert atmosphere

With potassium tert-butylate; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jo102294j