2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

Base Information

Chemical Name:2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate
CAS No.:1612853-73-2
Molecular Formula:C₃₇H₄₃N₅O₅
Molecular Weight:637.779
Hs Code.:

2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

Synonyms:2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

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Chemical Property of 2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

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Technology Process of 2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

There total 10 articles about 2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418128-76-3
acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl ester

: 1612853-65-2
5-bromo-3-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-1H-pyridin-2-one

: 1612853-73-2
2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

: 1612853-22-1
6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: With potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In water; butan-1-ol; at 100 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 64622-16-8
2-bromo-6-chlorobenzaldehyde

: 1612853-73-2
2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

: 1612853-22-1
6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 16.5 h / 90 °C / Inert atmosphere

2: sodium tetrahydroborate; isopropyl alcohol / dichloromethane / 1.25 h / 2 - 9 °C

3: pyridine / dichloromethane

4: palladium diacetate; potassium acetate; XPhos / 1,4-dioxane / 75 °C / Inert atmosphere

5: potassium phosphate; XPhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; butan-1-ol / 1.5 h / 100 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; potassium phosphate; potassium acetate; palladium diacetate; potassium carbonate; isopropyl alcohol; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1462328-88-6
6-tert-butyl-2-(3-chloro-2-hydroxymethylphenyl)-3,4-dihydro-2H-isoquinolin-1-one

: 1612853-73-2
2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

: 1612853-22-1
6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane

2: palladium diacetate; potassium acetate; XPhos / 1,4-dioxane / 75 °C / Inert atmosphere

3: potassium phosphate; XPhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; butan-1-ol / 1.5 h / 100 °C / Inert atmosphere

With pyridine; potassium phosphate; potassium acetate; palladium diacetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; dichloromethane; water; butan-1-ol;