6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Base Information

Chemical Name:6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one
CAS No.:1612853-22-1
Molecular Formula:C₃₅H₄₁N₅O₄
Molecular Weight:595.742
Hs Code.:

6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Synonyms:6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

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Chemical Property of 6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

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Technology Process of 6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

There total 21 articles about 6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1612853-73-2
2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

: 1612853-22-1
6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 60 ℃;

Reference yield:

: 1418128-76-3
acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl ester

: 1612853-65-2
5-bromo-3-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-1H-pyridin-2-one

: 1612853-73-2
2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(5-(5-((2-methoxyethylamino)methyl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

: 1612853-22-1
6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: With potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In water; butan-1-ol; at 100 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1242156-64-4
(5-bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-(5-formylpyridin-2-yl)carbamic acid tert-butyl ester

: 1612853-22-1
6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 40 °C

2: trifluoroacetic acid / dichloromethane / 6.5 h

3: potassium phosphate; XPhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; butan-1-ol / 1.5 h / 100 °C / Inert atmosphere

4: sodium hydroxide / tetrahydrofuran / 60 °C

With potassium phosphate; sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; dichloromethane; water; butan-1-ol;