(2S,5R)-2-((S)-2-(benzyloxymethyl)-3-methylbutyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine

Base Information

Chemical Name:(2S,5R)-2-((S)-2-(benzyloxymethyl)-3-methylbutyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine
CAS No.:953820-31-0
Molecular Formula:C₂₄H₃₈N₂O₃
Molecular Weight:402.577
Hs Code.:

Synonyms:(2S,5R)-2-((S)-2-(benzyloxymethyl)-3-methylbutyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine

Suppliers and Price of (2S,5R)-2-((S)-2-(benzyloxymethyl)-3-methylbutyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,5R)-2-((S)-2-(benzyloxymethyl)-3-methylbutyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,5R)-2-((S)-2-(benzyloxymethyl)-3-methylbutyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine

There total 6 articles about (2S,5R)-2-((S)-2-(benzyloxymethyl)-3-methylbutyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 110117-71-0
(2R)-3,6-diethoxy-2-isopropyl-2,5-dihydropyrazine

: 172901-00-7
(2S)-(benzyloxymethyl)-3-methyl-butyl bromide

: 953820-31-0
(2S,5R)-2-((S)-2-(benzyloxymethyl)-3-methylbutyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine

Guidance literature:: (2R)-3,6-diethoxy-2-isopropyl-2,5-dihydropyrazine; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 1.25h;

(2S)-(benzyloxymethyl)-3-methyl-butyl bromide; In tetrahydrofuran; hexanes; at -78 - -20 ℃; for 20.5h;

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 953820-31-0
(2S,5R)-2-((S)-2-(benzyloxymethyl)-3-methylbutyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C

1.2: 21.5 h / 0 °C

2.1: lithium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3.2: 0 °C

4.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 18 h / 0 - 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexanes / 1.25 h / -78 °C

5.2: 20.5 h / -78 - -20 °C

With lithium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; water; dihydrogen peroxide; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; hexanes; dichloromethane;

Reference yield:

: 365541-75-9
(2R)-3-methyl-2-[(phenylmethoxy)methyl]butan-1-ol

: 953820-31-0
(2S,5R)-2-((S)-2-(benzyloxymethyl)-3-methylbutyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 18 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.25 h / -78 °C

2.2: 20.5 h / -78 - -20 °C

With N-Bromosuccinimide; n-butyllithium; triphenylphosphine; In tetrahydrofuran; hexanes; dichloromethane;