3-(4-fluorophenyl)-2-{[(4-hydroxyphenyl)methylidene]hydrazinylidene}-1,3-thiazolidin-4-one

Base Information

Chemical Name:3-(4-fluorophenyl)-2-{[(4-hydroxyphenyl)methylidene]hydrazinylidene}-1,3-thiazolidin-4-one
CAS No.:16113-47-6
Molecular Formula:C₁₆H₁₂FN₃O₂S
Molecular Weight:329.355
Hs Code.:

Synonyms:3-(4-fluorophenyl)-2-{[(4-hydroxyphenyl)methylidene]hydrazinylidene}-1,3-thiazolidin-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-fluorophenyl)-2-{[(4-hydroxyphenyl)methylidene]hydrazinylidene}-1,3-thiazolidin-4-one

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Technology Process of 3-(4-fluorophenyl)-2-{[(4-hydroxyphenyl)methylidene]hydrazinylidene}-1,3-thiazolidin-4-one

There total 6 articles about 3-(4-fluorophenyl)-2-{[(4-hydroxyphenyl)methylidene]hydrazinylidene}-1,3-thiazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 16113-39-6
4-(4-fluorophenyl)-1-[(4-hydroxyphenyl)methylidene]-3-thiosemicarbazide

: 105-36-2
ethyl bromoacetate

: 16113-47-6
3-(4-fluorophenyl)-2-{[(4-hydroxyphenyl)methylidene]hydrazinylidene}-1,3-thiazolidin-4-one

Guidance literature:: With sodium acetate; In ethanol; for 2h; Reflux;
DOI:10.3390/molecules24173029

Reference yield:

: 330-94-9
4-(4-fluorophenyl)thiosemicarbazide

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 16113-47-6
3-(4-fluorophenyl)-2-{[(4-hydroxyphenyl)methylidene]hydrazinylidene}-1,3-thiazolidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / ethanol / Reflux

2: sodium acetate / ethanol / 2 h / Reflux

With sodium acetate; acetic acid; In ethanol;
DOI:10.3390/molecules24173029

Reference yield:

: 330-94-9
4-(4-fluorophenyl)thiosemicarbazide

: 16113-47-6
3-(4-fluorophenyl)-2-{[(4-hydroxyphenyl)methylidene]hydrazinylidene}-1,3-thiazolidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: AcOH / ethanol / Heating

2: NaOAc / acetic acid

With sodium acetate; acetic acid; In ethanol; acetic acid;