2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}-(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

Base Information

Chemical Name:2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}-(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid
CAS No.:1593269-82-9
Molecular Formula:C₃₁H₃₆N₂O₅
Molecular Weight:516.637
Hs Code.:

Synonyms:2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}-(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

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Chemical Property of 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}-(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

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Technology Process of 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}-(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

There total 8 articles about 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}-(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1593269-70-5
tert-butyl 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

: 1593269-82-9
2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}-(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;
DOI:10.1248/cpb.c13-00513

Reference yield:

: 101105-95-7
2-benzoylamino-4-methyl-3-oxo-pentanoic acid ethyl ester

: 1593269-82-9
2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}-(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / chloroform / 1 h / Reflux

2: lithium borohydride / tetrahydrofuran / 1 h / Reflux

3: thionyl chloride / chloroform / 2 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 40 °C

5: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

With hydrogenchloride; lithium borohydride; thionyl chloride; potassium carbonate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00513

Reference yield:

: 38603-76-8
ethyl 2-hydroxyimino-4-methyl-3-oxo-pentanoate

: 1593269-82-9
2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}-(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / ethanol / 20 °C

2: triethylammonium acetate / dichloromethane / 2 h / 20 °C

3: trichlorophosphate / chloroform / 1 h / Reflux

4: lithium borohydride / tetrahydrofuran / 1 h / Reflux

5: thionyl chloride / chloroform / 2 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 40 °C

7: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

With hydrogenchloride; lithium borohydride; thionyl chloride; palladium 10% on activated carbon; hydrogen; triethylammonium acetate; potassium carbonate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00513