tert-butyl 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

Base Information

• Chemical Name: tert-butyl 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate
• CAS No.: 1593269-70-5
• Molecular Formula: C₃₅H₄₄N₂O₅
• Molecular Weight: 572.745
• Mol file: 1593269-70-5.mol

Synonyms:tert-butyl 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

Chemical Property of tert-butyl 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

There total 7 articles about tert-butyl 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

C22H31NO4 (908598-34-5) + 4-(chloromethyl)-5-(propan-2-yl)-2-phenyl-1,3-oxazole (1593269-63-6) → tert-butyl 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate (1593269-70-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃;

DOI:10.1248/cpb.c13-00513

Reference yield:

ethyl 2-hydroxyimino-4-methyl-3-oxo-pentanoate (38603-76-8) → tert-butyl 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate (1593269-70-5)

Guidance literature:

Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / ethanol / 20 °C

2: triethylammonium acetate / dichloromethane / 2 h / 20 °C

3: trichlorophosphate / chloroform / 1 h / Reflux

4: lithium borohydride / tetrahydrofuran / 1 h / Reflux

5: thionyl chloride / chloroform / 2 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 40 °C

With hydrogenchloride; lithium borohydride; thionyl chloride; palladium 10% on activated carbon; hydrogen; triethylammonium acetate; potassium carbonate; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1248/cpb.c13-00513

Reference yield:

2-benzoylamino-4-methyl-3-oxo-pentanoic acid ethyl ester (101105-95-7) → tert-butyl 2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate (1593269-70-5)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / chloroform / 1 h / Reflux

2: lithium borohydride / tetrahydrofuran / 1 h / Reflux

3: thionyl chloride / chloroform / 2 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 40 °C

With lithium borohydride; thionyl chloride; potassium carbonate; trichlorophosphate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

DOI:10.1248/cpb.c13-00513

upstream raw materials:

C₂₂H₃₁NO₄

4-(chloromethyl)-5-(propan-2-yl)-2-phenyl-1,3-oxazole

2-benzoylamino-4-methyl-3-oxo-pentanoic acid ethyl ester

ethyl 4-methyl-3-oxo-pentanoate

Downstream raw materials:

2-(4-{[{[2-phenyl-5-(propan-2-yl)-1,3-oxazol-4-yl] methyl}-(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid