C₁₈H₁₈N₂O₅

Base Information

• Chemical Name: C₁₈H₁₈N₂O₅
• CAS No.: 1246617-13-9
• Molecular Formula: C₁₈H₁₈N₂O₅
• Molecular Weight: 342.351
• Mol file: 1246617-13-9.mol

Synonyms:C₁₈H₁₈N₂O₅

Chemical Property of C₁₈H₁₈N₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₈N₂O₅

There total 10 articles about C₁₈H₁₈N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H24N2O5 (1246617-12-8) → C18H18N2O5 (1246617-13-9)

Guidance literature:

C₂₅H₂₄N₂O₅; With trifluoroacetic acid; at 20 ℃; for 1h;

With hydrogenchloride; sodium hydrogencarbonate; In water; pH=3;

Reference yield:

1-amino-3-phenylpropan-2-ol hydrochloride (22820-51-5) → C18H18N2O5 (1246617-13-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

1.2: 2 h / 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 1 h / 20 °C

2.2: 2 h / 20 °C

3.1: hydrazine hydrate / tetrahydrofuran; methanol / 2 h / 50 °C

4.1: toluene / 2.5 h / 100 °C

5.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 3.5 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

8.1: trifluoroacetic acid / 1 h / 20 °C

8.2: pH 3

With hydrogenchloride; caesium carbonate; hydrazine hydrate; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

(RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol (162541-45-9) → C18H18N2O5 (1246617-13-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 1 h / 20 °C

1.2: 2 h / 20 °C

2.1: hydrazine hydrate / tetrahydrofuran; methanol / 2 h / 50 °C

3.1: toluene / 2.5 h / 100 °C

4.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 3.5 h / 20 °C

6.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

7.1: trifluoroacetic acid / 1 h / 20 °C

7.2: pH 3

With hydrogenchloride; caesium carbonate; hydrazine hydrate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

upstream raw materials:

1-amino-3-phenylpropan-2-ol hydrochloride

tert-butyl (2-amino-3-phenylpropyl)carbamate

(RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol

1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate