(Z)-6-(tert-butyldimethylsilyloxy)-6-(2-oxooxazolidin-3-yl)hex-5-enyl benzoate

Base Information

Chemical Name:(Z)-6-(tert-butyldimethylsilyloxy)-6-(2-oxooxazolidin-3-yl)hex-5-enyl benzoate
CAS No.:1330660-55-3
Molecular Formula:C₂₂H₃₃NO₅Si
Molecular Weight:419.593
Hs Code.:

Synonyms:(Z)-6-(tert-butyldimethylsilyloxy)-6-(2-oxooxazolidin-3-yl)hex-5-enyl benzoate

Suppliers and Price of (Z)-6-(tert-butyldimethylsilyloxy)-6-(2-oxooxazolidin-3-yl)hex-5-enyl benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Z)-6-(tert-butyldimethylsilyloxy)-6-(2-oxooxazolidin-3-yl)hex-5-enyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Z)-6-(tert-butyldimethylsilyloxy)-6-(2-oxooxazolidin-3-yl)hex-5-enyl benzoate

There total 3 articles about (Z)-6-(tert-butyldimethylsilyloxy)-6-(2-oxooxazolidin-3-yl)hex-5-enyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1330660-88-2
6-oxo-6-(2-oxooxazolidin-3-yl)hexyl benzoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1330660-55-3
(Z)-6-(tert-butyldimethylsilyloxy)-6-(2-oxooxazolidin-3-yl)hex-5-enyl benzoate

Guidance literature:: 6-oxo-6-(2-oxooxazolidin-3-yl)hexyl benzoate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

tert-butyldimethylsilyl chloride; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ja206050b

Reference yield:

: 6-benzoyloxyhexanoic acid

: 1330660-55-3
(Z)-6-(tert-butyldimethylsilyloxy)-6-(2-oxooxazolidin-3-yl)hex-5-enyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja206050b

Reference yield:

: 60405-63-2
6-hydroxyhexyl benzoate

: 1330660-55-3
(Z)-6-(tert-butyldimethylsilyloxy)-6-(2-oxooxazolidin-3-yl)hex-5-enyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; water / dichloromethane / 12 h / 20 °C

2.1: 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 4 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; n-butyllithium; [bis(acetoxy)iodo]benzene; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja206050b