ethyl N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-(7-cyano-2-naphthoyl)glycinate

Base Information

Chemical Name:ethyl N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-(7-cyano-2-naphthoyl)glycinate
CAS No.:221160-77-6
Molecular Formula:C₃₂H₃₅N₃O₆
Molecular Weight:557.646
Hs Code.:

Synonyms:ethyl N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-(7-cyano-2-naphthoyl)glycinate

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Chemical Property of ethyl N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-(7-cyano-2-naphthoyl)glycinate

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Technology Process of ethyl N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-(7-cyano-2-naphthoyl)glycinate

There total 4 articles about ethyl N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-(7-cyano-2-naphthoyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 105-36-2
ethyl bromoacetate

: 179756-35-5
N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-7-cyano-2-naphthamide

: 221160-77-6
ethyl N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-(7-cyano-2-naphthoyl)glycinate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(02)00106-2

Reference yield:

: 5043-08-3
7-cyanonaphthalene-2-carboxylic acid

: 221160-77-6
ethyl N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-(7-cyano-2-naphthoyl)glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / triethylamine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 24 h / 20 °C

2: 98 percent / sodium hydride / dimethylformamide / 1 h / 20 °C

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00106-2

Reference yield:

: 179756-49-1
7-formyl-2-naphthalene-carbonitrile

: 221160-77-6
ethyl N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-(7-cyano-2-naphthoyl)glycinate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / sodium chlorite / acetonitrile; H₂O / 20 h / Heating

2: 78 percent / triethylamine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 24 h / 20 °C

3: 98 percent / sodium hydride / dimethylformamide / 1 h / 20 °C

With sodium chlorite; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0968-0896(02)00106-2