4-[(Z)-2,3,3-Trifluoro-1-(toluene-4-sulfonyloxy)-propenyl]-benzoic acid ethyl ester

Base Information

• Chemical Name: 4-[(Z)-2,3,3-Trifluoro-1-(toluene-4-sulfonyloxy)-propenyl]-benzoic acid ethyl ester
• CAS No.: 164021-55-0
• Molecular Formula: C₁₉H₁₇F₃O₅S
• Molecular Weight: 414.402
• Mol file: 164021-55-0.mol

Synonyms:4-[(Z)-2,3,3-Trifluoro-1-(toluene-4-sulfonyloxy)-propenyl]-benzoic acid ethyl ester

Chemical Property of 4-[(Z)-2,3,3-Trifluoro-1-(toluene-4-sulfonyloxy)-propenyl]-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-[(Z)-2,3,3-Trifluoro-1-(toluene-4-sulfonyloxy)-propenyl]-benzoic acid ethyl ester

There total 1 articles about 4-[(Z)-2,3,3-Trifluoro-1-(toluene-4-sulfonyloxy)-propenyl]-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-iodobenzoic acid ethyl ester (51934-41-9) + 2,3,3-trifluoro-1-propenyl tosylate → 4-[(Z)-2,3,3-Trifluoro-1-(toluene-4-sulfonyloxy)-propenyl]-benzoic acid ethyl ester (164021-55-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; zinc dibromide; Yield given. Multistep reaction;

DOI:10.1246/cl.1995.239

Reference yield: 86.0%

methylhydrazine (60-34-4) + 4-[(Z)-2,3,3-Trifluoro-1-(toluene-4-sulfonyloxy)-propenyl]-benzoic acid ethyl ester (164021-55-0) → 4-(4-Fluoro-1-methyl-1H-pyrazol-3-yl)-benzoic acid ethyl ester

Guidance literature:

With tetrabutyl ammonium fluoride; In dimethyl sulfoxide; at 70 ℃; for 1h;

DOI:10.1246/cl.1995.239

Reference yield:

benzamidine monohydrochloride (1670-14-0) + 4-[(Z)-2,3,3-Trifluoro-1-(toluene-4-sulfonyloxy)-propenyl]-benzoic acid ethyl ester (164021-55-0) → 4-(5-Fluoro-2-phenyl-pyrimidin-4-yl)-benzoic acid ethyl ester

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; Yield given. Multistep reaction; 1.) methanol, RT, 0.5 h, 2.) DMSO, 70 deg C, 1 h;

DOI:10.1246/cl.1995.239

upstream raw materials:

4-iodobenzoic acid ethyl ester