3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester

Base Information

• Chemical Name: 3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester
• CAS No.: 171563-22-7
• Molecular Formula: C₁₄H₁₅NO₅
• Molecular Weight: 277.277
• Mol file: 171563-22-7.mol

Synonyms:3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester

Chemical Property of 3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester

There total 2 articles about 3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetyl chloride (75-36-5) + benzyl (4S,5R)-5-methyl-2-oxo-1,3-oxazolidine-4-carboxylate (171563-10-3) → 3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester (171563-22-7)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 16 ℃; for 20h;

DOI:10.1039/b501017a

Reference yield:

acetic anhydride (108-24-7) + benzyl (4S,5R)-5-methyl-2-oxo-1,3-oxazolidine-4-carboxylate (171563-10-3) → 3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester (171563-22-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/00404-0399(50)1348L-

Reference yield: 100.0%

3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid benzyl ester (171563-22-7) → (4S,5R)-3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid (171563-06-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 1h; under 2280 Torr;

DOI:10.1039/b501017a

upstream raw materials:

acetic anhydride

benzyl (4S,5R)-5-methyl-2-oxo-1,3-oxazolidine-4-carboxylate

acetyl chloride

Downstream raw materials:

(4S,5R)-3-acetyl-5-methyl-2-oxo-oxazolidine-4-carboxylic acid