N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

Base Information

Chemical Name:N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide
CAS No.:137302-68-2
Molecular Formula:C₃₆H₅₇F₂N₇O₇S
Molecular Weight:769.954
Hs Code.:

N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

Synonyms:N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

Suppliers and Price of N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

There total 10 articles about N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 137302-82-0
N-(1-piperazinylsulfonyl)-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

: 137302-68-2
N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

Guidance literature:: With formic acid; In ethanol; for 3h; Heating;
DOI:10.1021/jm00079a001

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 137302-68-2
N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

Guidance literature:: Multi-step reaction with 7 steps

1: 56 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

2: 93 percent / HCl gas / CHCl₃; methanol / 1 h / Ambient temperature

3: 80 percent / HOBT, DCC / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) RT, 16 h

4: 3.50 g / HCl gas / CH₂Cl₂; methanol / 0.25 h / Ambient temperature

5: HOBT, DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

6: HCl / CHCl₃

7: 59 percent / formic acid / ethanol / 3 h / Heating

With hydrogenchloride; formic acid; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00079a001

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 137302-68-2
N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

Guidance literature:: Multi-step reaction with 9 steps

1: Zn, I₂ / tetrahydrofuran / 0.5 h / Heating

2: 79 percent / NaOH / tetrahydrofuran / 4 h

3: 56 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

4: 93 percent / HCl gas / CHCl₃; methanol / 1 h / Ambient temperature

5: 80 percent / HOBT, DCC / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) RT, 16 h

6: 3.50 g / HCl gas / CH₂Cl₂; methanol / 0.25 h / Ambient temperature

7: HOBT, DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

8: HCl / CHCl₃

9: 59 percent / formic acid / ethanol / 3 h / Heating

With hydrogenchloride; sodium hydroxide; formic acid; iodine; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00079a001