Technology Process of 2-hydroxybenzoic acid 5-(3-vinyloxiranyl)pentyl ester
There total 5 articles about 2-hydroxybenzoic acid 5-(3-vinyloxiranyl)pentyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(3-vinyloxiranyl)pentane-1-ol;
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
for 0.35h;
Inert atmosphere;
salicylic acid;
In
tetrahydrofuran;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1039/c3ob41020j
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 2 h / 20 °C
1.2: 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: sodium hydroxide; benzyltrimethylammonium chloride / methanol; dichloromethane / -20 - 20 °C
4.1: ammonium fluoride / methanol / 8 h / Reflux
5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.35 h / Inert atmosphere
5.2: 12 h / 20 °C / Inert atmosphere
With
ammonium fluoride; oxalyl dichloride; di-isopropyl azodicarboxylate; benzyltrimethylammonium chloride; sodium hydride; dimethyl sulfoxide; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; mineral oil;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1039/c3ob41020j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide; benzyltrimethylammonium chloride / methanol; dichloromethane / -20 - 20 °C
2.1: ammonium fluoride / methanol / 8 h / Reflux
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.35 h / Inert atmosphere
3.2: 12 h / 20 °C / Inert atmosphere
With
ammonium fluoride; di-isopropyl azodicarboxylate; benzyltrimethylammonium chloride; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/c3ob41020j
